22,23-dihydrobrassicasterol is a lipid of Sterol Lipids (ST) class. 22,23-dihydrobrassicasterol is associated with abnormalities such as Diabetes, Macular degeneration, Drusen, Systemic disease and Diabetes Mellitus. The involved functions are known as cholesterol metabolism, Synthesis, Intestinal Absorption, Liver function and cholesterol absorption. 22,23-dihydrobrassicasterol often locates in Back and Cell membrane. The associated genes with 22,23-dihydrobrassicasterol are apolipoprotein E-3. The related lipids are Total cholesterol, campesterol, lathosterol, Fatty Acids, Nonesterified and Cholesterol, Dietary.
To understand associated biological information of 22,23-dihydrobrassicasterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22,23-dihydrobrassicasterol is suspected in Diabetes, Macular degeneration, Drusen, Systemic disease, Diabetes Mellitus, Liver diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 22,23-dihydrobrassicasterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Disease | D003327 | 70 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypolipoproteinemias | D007009 | 9 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schaeffer A et al. | The ratio of campesterol to sitosterol that modulates growth in Arabidopsis is controlled by STEROL METHYLTRANSFERASE 2;1. | 2001 | Plant J. | pmid:11319028 |
| Normén AL et al. | Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on Diet and Cancer. | 2001 | Am. J. Clin. Nutr. | pmid:11451730 |
| Meguro S et al. | Solubilization of phytosterols in diacylglycerol versus triacylglycerol improves the serum cholesterol-lowering effect. | 2001 | Eur J Clin Nutr | pmid:11464223 |
| Li JH et al. | Measurement variability of plasma beta-sitosterol and campesterol, two new biomarkers for cancer prevention. | 2001 | Eur. J. Cancer Prev. | pmid:11432711 |
| Relas H et al. | Acute effect of dietary stanyl ester dose on post-absorptive alpha-tocopherol, beta-carotene, retinol and retinyl palmitate concentrations. | 2001 | Br. J. Nutr. | pmid:11242481 |
| Tammi A et al. | Dietary plant sterols alter the serum plant sterol concentration but not the cholesterol precursor sterol concentrations in young children (the STRIP Study). Special Turku Coronary Risk Factor Intervention Project. | 2001 | J. Nutr. | pmid:11435511 |
| Tilvis RS et al. | Cholesterol and all-cause mortality in Honolulu. | 2001 | Lancet | pmid:11741659 |
| Relas H et al. | Fate of intravenously administered squalene and plant sterols in human subjects. | 2001 | J. Lipid Res. | pmid:11369807 |
| Ikeda I et al. | Mechanisms of phytosterolemia in stroke-prone spontaneously hypertensive and WKY rats. | 2001 | Metab. Clin. Exp. | pmid:11699058 |
| Yu L et al. | Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12444248 |
| Sehayek E et al. | Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J x CASA/Rk intercross. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12446833 |
| Vanstone CA et al. | Unesterified plant sterols and stanols lower LDL-cholesterol concentrations equivalently in hypercholesterolemic persons. | 2002 | Am. J. Clin. Nutr. | pmid:12450893 |
| Boggia R et al. | Classification and class-modeling of "Riviera Ligure" extra-virgin olive oil using chemical-physical parameters. | 2002 | J. Agric. Food Chem. | pmid:11929311 |
| Plat J and Mensink RP | Relationship of genetic variation in genes encoding apolipoprotein A-IV, scavenger receptor BI, HMG-CoA reductase, CETP and apolipoprotein E with cholesterol metabolism and the response to plant stanol ester consumption. | 2002 | Eur. J. Clin. Invest. | pmid:11952809 |
| Holmberg N et al. | Sterol C-24 methyltransferase type 1 controls the flux of carbon into sterol biosynthesis in tobacco seed. | 2002 | Plant Physiol. | pmid:12226510 |
| Sudhop T et al. | Serum plant sterols as a potential risk factor for coronary heart disease. | 2002 | Metab. Clin. Exp. | pmid:12489060 |
| Ijzerman RG et al. | The association between low birth weight and high levels of cholesterol is not due to an increased cholesterol synthesis or absorption: analysis in twins. | 2002 | Pediatr. Res. | pmid:12438663 |
| Khripach VA et al. | [3,3]-Claisen rearrangements in 24alpha-methyl steroid synthesis. Application to campesterol, crinosterol, and Delta25-crinosterol side chain construction. | 2002 | Steroids | pmid:11996932 |
| De Graaf J et al. | Consumption of tall oil-derived phytosterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels. | 2002 | Br. J. Nutr. | pmid:12425728 |
| Sudhop T et al. | Comparison of the hepatic clearances of campesterol, sitosterol, and cholesterol in healthy subjects suggests that efflux transporters controlling intestinal sterol absorption also regulate biliary secretion. | 2002 | Gut | pmid:12427790 |