22,23-dihydrobrassicasterol is a lipid of Sterol Lipids (ST) class. 22,23-dihydrobrassicasterol is associated with abnormalities such as Diabetes, Macular degeneration, Drusen, Systemic disease and Diabetes Mellitus. The involved functions are known as cholesterol metabolism, Synthesis, Intestinal Absorption, Liver function and cholesterol absorption. 22,23-dihydrobrassicasterol often locates in Back and Cell membrane. The associated genes with 22,23-dihydrobrassicasterol are apolipoprotein E-3. The related lipids are Total cholesterol, campesterol, lathosterol, Fatty Acids, Nonesterified and Cholesterol, Dietary.
To understand associated biological information of 22,23-dihydrobrassicasterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22,23-dihydrobrassicasterol is suspected in Diabetes, Macular degeneration, Drusen, Systemic disease, Diabetes Mellitus, Liver diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 22,23-dihydrobrassicasterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Disease | D003327 | 70 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypolipoproteinemias | D007009 | 9 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Miettinen TA et al. | Relation of non-cholesterol sterols to coronary risk factors and carotid intima-media thickness: the Cardiovascular Risk in Young Finns Study. | 2010 | Atherosclerosis | pmid:19963215 |
| Kempen HJ et al. | Lathosterol level in plasma is elevated in type III hyperlipoproteinemia, but not in non-type III subjects with apolipoprotein E2/2 phenotype, nor in type IIa or IIb hyperlipoproteinemia. | 1991 | Metab. Clin. Exp. | pmid:2000034 |
| Sharma M et al. | Inhibition of sterol biosynthesis reduces tombusvirus replication in yeast and plants. | 2010 | J. Virol. | pmid:20015981 |
| Forchielli ML et al. | The spectrum of plant and animal sterols in different oil-derived intravenous emulsions. | 2010 | Lipids | pmid:20049583 |
| Noto D et al. | Plasma non-cholesterol sterols: a useful diagnostic tool in pediatric hypercholesterolemia. | 2010 | Pediatr. Res. | pmid:20091938 |
| Miettinen TA et al. | Non-cholesterol sterols in serum and endarterectomized carotid arteries after a short-term plant stanol and sterol ester challenge. | 2011 | Nutr Metab Cardiovasc Dis | pmid:20096545 |
| Nikkilä K et al. | High cholestanol and low campesterol-to-sitosterol ratio in serum of patients with primary biliary cirrhosis before liver transplantation. | 1991 | Hepatology | pmid:2010161 |
| Chung HY et al. | Simultaneous suppression of three genes related to brassinosteroid (BR) biosynthesis altered campesterol and BR contents, and led to a dwarf phenotype in Arabidopsis thaliana. | 2010 | Plant Cell Rep. | pmid:20169349 |
| Han JH et al. | [Comparison of the dietary phytosterols intake and serum lipids content in elderly women from three cities of China]. | 2009 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:20193499 |
| Silbernagel G et al. | The associations of cholesterol metabolism and plasma plant sterols with all-cause and cardiovascular mortality. | 2010 | J. Lipid Res. | pmid:20228406 |
| van Dusseldorp M et al. | Cholesterol-raising factor from boiled coffee does not pass a paper filter. | 1991 May-Jun | Arterioscler. Thromb. | pmid:2029499 |
| Rossard S et al. | Ergosterol triggers characteristic elicitation steps in Beta vulgaris leaf tissues. | 2010 | J. Exp. Bot. | pmid:20304987 |
| Clément C et al. | Influence of colour type and previous cultivation on secondary metabolites in hypocotyls and leaves of maca (Lepidium meyenii Walpers). | 2010 | J. Sci. Food Agric. | pmid:20355123 |
| Kuriyama M et al. | High levels of plant sterols and cholesterol precursors in cerebrotendinous xanthomatosis. | 1991 | J. Lipid Res. | pmid:2066659 |
| Hang J and Dussault P | A concise synthesis of beta-sitosterol and other phytosterols. | 2010 | Steroids | pmid:20685279 |
| Lupattelli G et al. | Non-cholesterol sterols in different forms of primary hyperlipemias. | 2012 | Nutr Metab Cardiovasc Dis | pmid:20708389 |
| Okada K et al. | Lipid-lowering effects of ezetimibe for hypercholesterolemic patients with and without type 2 diabetes mellitus. | 2010 | Endocr. J. | pmid:20733267 |
| Shay CM et al. | Do plant sterol concentrations correlate with coronary artery disease in type 1 diabetes? A report from the Pittsburgh Epidemiology of Diabetes Complications Study. | 2009 | J Diabetes | pmid:20827426 |
| Hattori S and Hattori Y | Efficacy and safety of ezetimibe in patients undergoing hemodialysis. | 2010 | Endocr. J. | pmid:20885068 |
| Neil HA et al. | Impact of atorvastatin and omega-3 ethyl esters 90 on plasma plant sterol concentrations and cholesterol synthesis in type 2 diabetes: a randomised placebo controlled factorial trial. | 2010 | Atherosclerosis | pmid:21036355 |