22,23-dihydrobrassicasterol is a lipid of Sterol Lipids (ST) class. 22,23-dihydrobrassicasterol is associated with abnormalities such as Diabetes, Macular degeneration, Drusen, Systemic disease and Diabetes Mellitus. The involved functions are known as cholesterol metabolism, Synthesis, Intestinal Absorption, Liver function and cholesterol absorption. 22,23-dihydrobrassicasterol often locates in Back and Cell membrane. The associated genes with 22,23-dihydrobrassicasterol are apolipoprotein E-3. The related lipids are Total cholesterol, campesterol, lathosterol, Fatty Acids, Nonesterified and Cholesterol, Dietary.
To understand associated biological information of 22,23-dihydrobrassicasterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22,23-dihydrobrassicasterol is suspected in Diabetes, Macular degeneration, Drusen, Systemic disease, Diabetes Mellitus, Liver diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 22,23-dihydrobrassicasterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Disease | D003327 | 70 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypolipoproteinemias | D007009 | 9 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Baker VA et al. | Safety evaluation of phytosterol esters. Part 1. Assessment of oestrogenicity using a combination of in vivo and in vitro assays. | 1999 | Food Chem. Toxicol. | pmid:10069478 |
| Choe S et al. | The Arabidopsis dwarf1 mutant is defective in the conversion of 24-methylenecholesterol to campesterol in brassinosteroid biosynthesis. | 1999 | Plant Physiol. | pmid:10069828 |
| Gylling H et al. | Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population. | 1999 | J. Lipid Res. | pmid:10191283 |
| Strom SS et al. | Phytoestrogen intake and prostate cancer: a case-control study using a new database. | 1999 | Nutr Cancer | pmid:10227039 |
| Jones PJ et al. | Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. | 1999 | Am. J. Clin. Nutr. | pmid:10357732 |
| Noguchi T et al. | Arabidopsis det2 is defective in the conversion of (24R)-24-methylcholest-4-En-3-one to (24R)-24-methyl-5alpha-cholestan-3-one in brassinosteroid biosynthesis. | 1999 | Plant Physiol. | pmid:10398719 |
| Bortolomeazzi R et al. | Mass spectrometry characterization of the 5alpha-, 7alpha-, and 7beta-hydroxy derivatives of beta-sitosterol, campesterol, stigmasterol, and brassicasterol. | 1999 | J. Agric. Food Chem. | pmid:10552610 |
| Mensenkamp AR et al. | Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver. | 1999 | J. Biol. Chem. | pmid:10585451 |
| Nguyen TT et al. | Cholesterol-lowering effect of stanol ester in a US population of mildly hypercholesterolemic men and women: a randomized controlled trial. | 1999 | Mayo Clin. Proc. | pmid:10593347 |
| Rajaratnam RA et al. | Independent association of serum squalene and noncholesterol sterols with coronary artery disease in postmenopausal women. | 2000 | J. Am. Coll. Cardiol. | pmid:10758959 |
| Awad AB et al. | Inhibition of growth and stimulation of apoptosis by beta-sitosterol treatment of MDA-MB-231 human breast cancer cells in culture. | 2000 | Int. J. Mol. Med. | pmid:10762659 |
| Miettinen TA et al. | Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine. | 2000 | Am. J. Clin. Nutr. | pmid:10799370 |
| Miettinen TA et al. | Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10807752 |
| Sanders DJ et al. | The safety evaluation of phytosterol esters. Part 6. The comparative absorption and tissue distribution of phytosterols in the rat. | 2000 | Food Chem. Toxicol. | pmid:10828500 |
| Seto H et al. | Synthesis of 6-oxy functionalized campest-4-en-3-ones: efficient hydroperoxidation at C-6 of campest-5-en-3-one with molecular oxygen and silica gel. | 2000 | Steroids | pmid:10936615 |
| Relas H et al. | Dietary squalene increases cholesterol synthesis measured with serum non-cholesterol sterols after a single oral dose in humans. | 2000 | Atherosclerosis | pmid:10998465 |
| Salen G et al. | Hyperabsorption and retention of campestanol in a sitosterolemic homozygote: comparison with her mother and three control subjects. | 2000 | J. Lipid Res. | pmid:11060358 |
| Song YS et al. | Identification of metabolites of phytosterols in rat feces using GC/MS. | 2000 | Arch. Pharm. Res. | pmid:11156182 |
| Relas H et al. | Acute effect of dietary stanyl ester dose on post-absorptive alpha-tocopherol, beta-carotene, retinol and retinyl palmitate concentrations. | 2001 | Br. J. Nutr. | pmid:11242481 |
| Cui YJ et al. | Biotransformation of 24 alpha-methylcholesterol and 24 beta-methylcholesterol by yeast mutant GL7. | 1999 | J Asian Nat Prod Res | pmid:11261204 |
| Schaeffer A et al. | The ratio of campesterol to sitosterol that modulates growth in Arabidopsis is controlled by STEROL METHYLTRANSFERASE 2;1. | 2001 | Plant J. | pmid:11319028 |
| Relas H et al. | Fate of intravenously administered squalene and plant sterols in human subjects. | 2001 | J. Lipid Res. | pmid:11369807 |
| Li JH et al. | Measurement variability of plasma beta-sitosterol and campesterol, two new biomarkers for cancer prevention. | 2001 | Eur. J. Cancer Prev. | pmid:11432711 |
| Tammi A et al. | Dietary plant sterols alter the serum plant sterol concentration but not the cholesterol precursor sterol concentrations in young children (the STRIP Study). Special Turku Coronary Risk Factor Intervention Project. | 2001 | J. Nutr. | pmid:11435511 |
| Normén AL et al. | Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on Diet and Cancer. | 2001 | Am. J. Clin. Nutr. | pmid:11451730 |
| Meguro S et al. | Solubilization of phytosterols in diacylglycerol versus triacylglycerol improves the serum cholesterol-lowering effect. | 2001 | Eur J Clin Nutr | pmid:11464223 |
| Ikeda I et al. | Mechanisms of phytosterolemia in stroke-prone spontaneously hypertensive and WKY rats. | 2001 | Metab. Clin. Exp. | pmid:11699058 |
| Tilvis RS et al. | Cholesterol and all-cause mortality in Honolulu. | 2001 | Lancet | pmid:11741659 |
| Mensink RP et al. | Effects of plant stanol esters supplied in low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations. | 2002 | Atherosclerosis | pmid:11755939 |
| Brämswig S et al. | Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11788421 |
| Beveridge TH et al. | Phytosterol content in American ginseng seed oil. | 2002 | J. Agric. Food Chem. | pmid:11829639 |
| Ostlund RE et al. | Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11882512 |
| Awad AB et al. | In vitro and in vivo (SCID mice) effects of phytosterols on the growth and dissemination of human prostate cancer PC-3 cells. | 2001 | Eur. J. Cancer Prev. | pmid:11916349 |
| Boggia R et al. | Classification and class-modeling of "Riviera Ligure" extra-virgin olive oil using chemical-physical parameters. | 2002 | J. Agric. Food Chem. | pmid:11929311 |
| Plat J and Mensink RP | Relationship of genetic variation in genes encoding apolipoprotein A-IV, scavenger receptor BI, HMG-CoA reductase, CETP and apolipoprotein E with cholesterol metabolism and the response to plant stanol ester consumption. | 2002 | Eur. J. Clin. Invest. | pmid:11952809 |
| Khripach VA et al. | [3,3]-Claisen rearrangements in 24alpha-methyl steroid synthesis. Application to campesterol, crinosterol, and Delta25-crinosterol side chain construction. | 2002 | Steroids | pmid:11996932 |
| Nissinen M et al. | Micellar distribution of cholesterol and phytosterols after duodenal plant stanol ester infusion. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12016126 |
| Lindenthal B et al. | Serum plant sterols and biliary cholesterol secretion in humans: studies with ursodeoxycholic acid. | 2002 | J. Lipid Res. | pmid:12091491 |
| Khabazian I et al. | Isolation of various forms of sterol beta-D-glucoside from the seed of Cycas circinalis: neurotoxicity and implications for ALS-parkinsonism dementia complex. | 2002 | J. Neurochem. | pmid:12153476 |
| Hallikainen M et al. | Short-term LDL cholesterol-lowering efficacy of plant stanol esters. | 2002 | BMC Cardiovasc Disord | pmid:12197945 |
| Clouse SD | Arabidopsis mutants reveal multiple roles for sterols in plant development. | 2002 | Plant Cell | pmid:12215500 |
| Holmberg N et al. | Sterol C-24 methyltransferase type 1 controls the flux of carbon into sterol biosynthesis in tobacco seed. | 2002 | Plant Physiol. | pmid:12226510 |
| De Graaf J et al. | Consumption of tall oil-derived phytosterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels. | 2002 | Br. J. Nutr. | pmid:12425728 |
| Sudhop T et al. | Comparison of the hepatic clearances of campesterol, sitosterol, and cholesterol in healthy subjects suggests that efflux transporters controlling intestinal sterol absorption also regulate biliary secretion. | 2002 | Gut | pmid:12427790 |
| Ijzerman RG et al. | The association between low birth weight and high levels of cholesterol is not due to an increased cholesterol synthesis or absorption: analysis in twins. | 2002 | Pediatr. Res. | pmid:12438663 |
| Yu L et al. | Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12444248 |
| Sehayek E et al. | Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J x CASA/Rk intercross. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12446833 |
| Vanstone CA et al. | Unesterified plant sterols and stanols lower LDL-cholesterol concentrations equivalently in hypercholesterolemic persons. | 2002 | Am. J. Clin. Nutr. | pmid:12450893 |
| Sudhop T et al. | Serum plant sterols as a potential risk factor for coronary heart disease. | 2002 | Metab. Clin. Exp. | pmid:12489060 |
| Teunissen CE et al. | Serum cholesterol, precursors and metabolites and cognitive performance in an aging population. | 2003 Jan-Feb | Neurobiol. Aging | pmid:12493560 |
| Miettinen TA et al. | Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins. | 2003 | J. Lab. Clin. Med. | pmid:12577049 |
| Chan DC et al. | Relationships between cholesterol homoeostasis and triacylglycerol-rich lipoprotein remnant metabolism in the metabolic syndrome. | 2003 | Clin. Sci. | pmid:12653682 |
| Awad AB et al. | Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells. | 2003 | J. Nutr. Biochem. | pmid:12667603 |
| Schaller H | The role of sterols in plant growth and development. | 2003 | Prog. Lipid Res. | pmid:12689617 |
| Chan DC et al. | Plasma markers of cholesterol homeostasis and apolipoprotein B-100 kinetics in the metabolic syndrome. | 2003 | Obes. Res. | pmid:12690090 |
| Gorinstein S et al. | Comparison of the contents of the main biochemical compounds and the antioxidant activity of some Spanish olive oils as determined by four different radical scavenging tests. | 2003 | J. Nutr. Biochem. | pmid:12742543 |
| Hendriks HF et al. | Safety of long-term consumption of plant sterol esters-enriched spread. | 2003 | Eur J Clin Nutr | pmid:12771969 |
| Watts GF et al. | Effect of a statin on hepatic apolipoprotein B-100 secretion and plasma campesterol levels in the metabolic syndrome. | 2003 | Int. J. Obes. Relat. Metab. Disord. | pmid:12821974 |
| Ntanios FY et al. | Effects of various amounts of dietary plant sterol esters on plasma and hepatic sterol concentration and aortic foam cell formation of cholesterol-fed hamsters. | 2003 | Atherosclerosis | pmid:12860249 |
| von Bonsdorff-Nikander A et al. | Physical stability of a microcrystalline beta-sitosterol suspension in oil. | 2003 | Eur J Pharm Sci | pmid:12885381 |
| Mezine I et al. | Analysis of plant sterol and stanol esters in cholesterol-lowering spreads and beverages using high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectroscopy. | 2003 | J. Agric. Food Chem. | pmid:12952413 |
| KALLIANOS AG et al. | Identification of the D-glucosides of stigmasterol, sitosterol and campesterol in tobacco and cigarette smoke. | 1963 | Biochem. J. | pmid:14030353 |
| Graf GA et al. | ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. | 2003 | J. Biol. Chem. | pmid:14504269 |
| Bloks VW et al. | Down-regulation of hepatic and intestinal Abcg5 and Abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes. | 2004 | Diabetologia | pmid:14618236 |
| Plösch T et al. | Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor. | 2004 | Gastroenterology | pmid:14699507 |
| Devaraj S et al. | Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14764424 |
| Salen G et al. | Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia. | 2004 | Circulation | pmid:14769702 |
| Nikkilä K et al. | Liver transplantation modifies serum cholestanol, cholesterol precursor and plant sterol levels. | 1992 | Clin. Chim. Acta | pmid:1499139 |
| Klett EL et al. | A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. | 2004 | BMC Med | pmid:15040800 |
| Ketomaki A et al. | Effects of plant stanol and sterol esters on serum phytosterols in a family with familial hypercholesterolemia including a homozygous subject. | 2004 | J. Lab. Clin. Med. | pmid:15085084 |
| Delaney B et al. | Oral absorption of phytosterols and emulsified phytosterols by Sprague-Dawley rats. | 2004 | J. Nutr. Biochem. | pmid:15135153 |
| Mongrand S et al. | Lipid rafts in higher plant cells: purification and characterization of Triton X-100-insoluble microdomains from tobacco plasma membrane. | 2004 | J. Biol. Chem. | pmid:15190066 |
| Amundsen AL et al. | Long-term compliance and changes in plasma lipids, plant sterols and carotenoids in children and parents with FH consuming plant sterol ester-enriched spread. | 2004 | Eur J Clin Nutr | pmid:15199384 |
| Vanhanen HT and Miettinen TA | Effects of unsaturated and saturated dietary plant sterols on their serum contents. | 1992 | Clin. Chim. Acta | pmid:1521345 |
| Tomoyori H et al. | Phytosterol oxidation products are absorbed in the intestinal lymphatics in rats but do not accelerate atherosclerosis in apolipoprotein E-deficient mice. | 2004 | J. Nutr. | pmid:15226455 |
| Nomura T et al. | Brassinosteroid deficiency due to truncated steroid 5alpha-reductase causes dwarfism in the lk mutant of pea. | 2004 | Plant Physiol. | pmid:15286289 |
| Pakarinen MP et al. | Growth hormone selectively improves intestinal cholesterol absorption after jejunoileal autotransplantation in pigs. | 2004 | J. Pediatr. Surg. | pmid:15300531 |
| Marcone MF et al. | Amaranth as a rich dietary source of beta-sitosterol and other phytosterols. | 2003 | Plant Foods Hum Nutr | pmid:15366261 |
| Yang C et al. | Disruption of cholesterol homeostasis by plant sterols. | 2004 | J. Clin. Invest. | pmid:15372105 |
| Lembcke J et al. | Rapid quantification of free and esterified phytosterols in human serum using APPI-LC-MS/MS. | 2005 | J. Lipid Res. | pmid:15489546 |
| Plat J et al. | Common sequence variations in ABCG8 are related to plant sterol metabolism in healthy volunteers. | 2005 | J. Lipid Res. | pmid:15520451 |
| Nikkilä K et al. | Sterol parameters as markers of liver function in primary biliary cirrhosis before and after liver transplantation. | 2005 | Transpl. Int. | pmid:15691276 |
| Yokosuka A et al. | New glycosides of the campesterol derivative from the rhizomes of Tacca chantrieri. | 2005 | Steroids | pmid:15784281 |
| Yu L et al. | Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8. | 2005 | J. Lipid Res. | pmid:15930515 |
| Miettinen TA et al. | Plant sterols in serum and in atherosclerotic plaques of patients undergoing carotid endarterectomy. | 2005 | J. Am. Coll. Cardiol. | pmid:15936608 |
| Hong Z et al. | The Rice brassinosteroid-deficient dwarf2 mutant, defective in the rice homolog of Arabidopsis DIMINUTO/DWARF1, is rescued by the endogenously accumulated alternative bioactive brassinosteroid, dolichosterone. | 2005 | Plant Cell | pmid:15994910 |
| Päivä H et al. | High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial. | 2005 | Clin. Pharmacol. Ther. | pmid:16003294 |
| Sutherland WH et al. | Plasma non-cholesterol sterols in patients with non-insulin dependent diabetes mellitus. | 1992 | Horm. Metab. Res. | pmid:1601392 |
| Awad AB et al. | beta-Sitosterol stimulates ceramide metabolism in differentiated Caco2 cells. | 2005 | J. Nutr. Biochem. | pmid:16098730 |
| Ho SS and Pal S | Margarine phytosterols decrease the secretion of atherogenic lipoproteins from HepG2 liver and Caco2 intestinal cells. | 2005 | Atherosclerosis | pmid:16115472 |
| Conchillo A et al. | Levels of phytosterol oxides in enriched and nonenriched spreads: application of a thin-layer chromatography-gas chromatography methodology. | 2005 | J. Agric. Food Chem. | pmid:16190640 |
| Xu F et al. | Dual roles for cholesterol in mammalian cells. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16199524 |
| Takahashi K et al. | Metabolic conversion of 24-methyl-Delta25-cholesterol to 24-methylcholesterol in higher plants. | 2006 | Bioorg. Med. Chem. | pmid:16213729 |
| de Jong A et al. | Plant sterol or stanol consumption does not affect erythrocyte osmotic fragility in patients on statin treatment. | 2006 | Eur J Clin Nutr | pmid:16482072 |
| Hedman M et al. | Serum noncholesterol sterols in children with heterozygous familial hypercholesterolemia undergoing pravastatin therapy. | 2006 | J. Pediatr. | pmid:16492436 |
| Takahashi K et al. | Purification and ATPase activity of human ABCA1. | 2006 | J. Biol. Chem. | pmid:16500904 |
| Sorenson WR and Sullivan D | Determination of campesterol, stigmasterol, and beta-sitosterol in saw palmetto raw materials and dietary supplements by gas chromatography: single-laboratory validation. | 2006 Jan-Feb | J AOAC Int | pmid:16512224 |
| Gerloff T et al. | Influence of the SLCO1B1*1b and *5 haplotypes on pravastatin's cholesterol lowering capabilities and basal sterol serum levels. | 2006 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16568260 |
| Ikeda I et al. | Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARalpha, promotes energy consumption and reduces visceral fat deposition in rats. | 2006 | Biochim. Biophys. Acta | pmid:16616424 |