Dihydro-sitosterol

Dihydro-sitosterol is a lipid of Sterol Lipids (ST) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 152 references associated with Dihydro-sitosterol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Dihydro-sitosterol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Dihydro-sitosterol

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hypolipoproteinemias D007009 9 associated lipids
Total 3

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Hamdan IJA et al. Sterols in infant formulas: validation of a gas chromatographic method. 2017 Int J Food Sci Nutr pmid:28276904
Othman RA et al. Thyroid Hormone Status in Sitosterolemia Is Modified by Ezetimibe. 2017 J. Pediatr. pmid:28625503
Wocheslander S et al. Identification of Acyl Chain Oxidation Products upon Thermal Treatment of a Mixture of Phytosteryl/-stanyl Linoleates. 2016 J. Agric. Food Chem. pmid:27933991
Arfaoui MO et al. Variation in oil content, fatty acid and phytosterols profile of Onopordum acanthium L. during seed development. 2014 Nat. Prod. Res. pmid:25103576
Harrault L et al. Are fecal stanols suitable to record and identify a pulse of human fecal contamination in short-term exposed shellfish? A microcosm study. 2014 Mar. Pollut. Bull. pmid:25455370
Varshosaz J et al. Comparing different sterol containing solid lipid nanoparticles for targeted delivery of quercetin in hepatocellular carcinoma. 2014 J Liposome Res pmid:24354715
Sistiaga A et al. The Neanderthal meal: a new perspective using faecal biomarkers. 2014 PLoS ONE pmid:24963925
Tse TJ et al. Reconstructing long-term trends in municipal sewage discharge into a small lake in northern Manitoba, Canada. 2014 Chemosphere pmid:24405965
Valerio MS et al. β-Sitosterol modulates TLR4 receptor expression and intracellular MyD88-dependent pathway activation in J774A.1 murine macrophages. 2013 Sep-Oct Cell. Immunol. pmid:24121260
He WS et al. Role of plant stanol derivatives in the modulation of cholesterol metabolism and liver gene expression in mice. 2013 Food Chem pmid:23578608
Marttinen M et al. Plant stanols induce intestinal tumor formation by up-regulating Wnt and EGFR signaling in Apc Min mice. 2013 J. Nutr. Biochem. pmid:22981369
Cusack LK et al. The food matrix and sterol characteristics affect the plasma cholesterol lowering of phytosterol/phytostanol. 2013 Adv Nutr pmid:24228192
Zhao J et al. Evaluation of the effect of plant sterols on the intestinal processing of cholesterol using an in vitro lipolysis model. 2012 Int J Pharm pmid:22850295
Gylling H et al. Serum and lipoprotein sitostanol and non-cholesterol sterols after an acute dose of plant stanol ester on its long-term consumption. 2012 Eur J Nutr pmid:21947207
Szakiel A et al. Triterpenoid content of berries and leaves of bilberry Vaccinium myrtillus from Finland and Poland. 2012 J. Agric. Food Chem. pmid:23157739
Brüll F et al. Beneficial effects of sitostanol on the attenuated immune function in asthma patients: results of an in vitro approach. 2012 PLoS ONE pmid:23091602
Derrien M et al. Origin of fecal contamination in waters from contrasted areas: stanols as Microbial Source Tracking markers. 2012 Water Res. pmid:22673347
Hąc-Wydro K et al. Properties of β-sitostanol/DPPC monolayers studied with Grazing Incidence X-ray Diffraction (GIXD) and Brewster Angle Microscopy. 2011 J Colloid Interface Sci pmid:21903220
Zarrouk W et al. Exploratory characterization of the unsaponifiable fraction of tunisian virgin olive oils by a global approach with HPLC-APCI-IT MS/MS analysis. 2010 J. Agric. Food Chem. pmid:20438134
Tsubakio-Yamamoto K et al. Current therapy for patients with sitosterolemia--effect of ezetimibe on plant sterol metabolism. 2010 J. Atheroscler. Thromb. pmid:20543520
Brüll F et al. TLR2 activation is essential to induce a Th1 shift in human peripheral blood mononuclear cells by plant stanols and plant sterols. 2010 J. Biol. Chem. pmid:19948716
Gershkovich P et al. Inhibition of intestinal absorption of cholesterol by surface-modified nanostructured aluminosilicate compounds. 2009 J Pharm Sci pmid:19090562
Schrøder M et al. Effect of rapeseed oil-derived plant sterol and stanol esters on atherosclerosis parameters in cholesterol-challenged heterozygous Watanabe heritable hyperlipidaemic rabbits. 2009 Br. J. Nutr. pmid:19772679
Laitinen K et al. Plant stanol ester spreads as components of a balanced diet for pregnant and breast-feeding women: evaluation of clinical safety. 2009 Br. J. Nutr. pmid:19017423
Han JH et al. [Comparison of the dietary phytosterols intake and serum lipids content in elderly women from three cities of China]. 2009 Zhonghua Yu Fang Yi Xue Za Zhi pmid:20193499
Daly TJ et al. Lack of genoprotective effect of phytosterols and conjugated linoleic acids on Caco-2 cells. 2009 Food Chem. Toxicol. pmid:19406198
Chen Q et al. Dietary phytosterols and phytostanols alter the expression of sterol-regulatory genes in SHRSP and WKY inbred rats. 2009 Ann. Nutr. Metab. pmid:19851062
Saim N et al. Chemometric approach to validating faecal sterols as source tracer for faecal contamination in water. 2009 Water Res. pmid:19896157
Jia X et al. Co-administration of berberine and plant stanols synergistically reduces plasma cholesterol in rats. 2008 Atherosclerosis pmid:18430428
Aherne SA and O'Brien NM Modulation of cytokine production by plant sterols in stimulated human Jurkat T cells. 2008 Mol Nutr Food Res pmid:18465778
Matsuoka K et al. Study of thermodynamic parameters for solubilization of plant sterol and stanol in bile salt micelles. 2008 Chem. Phys. Lipids pmid:18544343
Jain D et al. Corn fiber oil and sitostanol decrease cholesterol absorption independently of intestinal sterol transporters in hamsters. 2008 J. Nutr. Biochem. pmid:17601722
Fassbender K et al. Moderately elevated plant sterol levels are associated with reduced cardiovascular risk--the LASA study. 2008 Atherosclerosis pmid:17137582
Sehayek E and Hazen SL Cholesterol absorption from the intestine is a major determinant of reverse cholesterol transport from peripheral tissue macrophages. 2008 Arterioscler. Thromb. Vasc. Biol. pmid:18420997
Liu R et al. Phospholipid transfer protein-deficient mice absorb less cholesterol. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17641249
Nair VD et al. Determination of stigmasterol, beta-sitosterol and stigmastanol in oral dosage forms using high performance liquid chromatography with evaporative light scattering detection. 2006 J Pharm Biomed Anal pmid:16487675
Palmgrén JJ et al. Quantitative determination of cholesterol, sitosterol, and sitostanol in cultured Caco-2 cells by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. 2005 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:15914100
Plat J et al. Plant sterols and stanols: effects on mixed micellar composition and LXR (target gene) activation. 2005 J. Lipid Res. pmid:16150823
Duan LP et al. Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice. 2004 J. Lipid Res. pmid:15102882
Mel'nikov SM et al. Effect of phytosterols and phytostanols on the solubilization of cholesterol by dietary mixed micelles: an in vitro study. 2004 Chem. Phys. Lipids pmid:14725996
Soupas L et al. Effects of sterol structure, temperature, and lipid medium on phytosterol oxidation. 2004 J. Agric. Food Chem. pmid:15479011
Mel'nikov SM et al. Can cholesterol absorption be reduced by phytosterols and phytostanols via a cocrystallization mechanism? 2004 Chem. Phys. Lipids pmid:14706738
Wang DQ and Carey MC Measurement of intestinal cholesterol absorption by plasma and fecal dual-isotope ratio, mass balance, and lymph fistula methods in the mouse: an analysis of direct versus indirect methodologies. 2003 J. Lipid Res. pmid:12588946
Miettinen TA and Gylling H Non-nutritive bioactive constituents of plants: phytosterols. 2003 Int J Vitam Nutr Res pmid:12747220
Sudhop T et al. Comparison of the effects of sitostanol, sitostanol acetate, and sitostanol oleate on the inhibition of cholesterol absorption in normolipemic healthy male volunteers. A placebo controlled randomized cross-over study. 2003 Arzneimittelforschung pmid:14650363
Igel M et al. Comparison of the intestinal uptake of cholesterol, plant sterols, and stanols in mice. 2003 J. Lipid Res. pmid:12562824
Mezine I et al. Analysis of plant sterol and stanol esters in cholesterol-lowering spreads and beverages using high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectroscopy. 2003 J. Agric. Food Chem. pmid:12952413
Yu L et al. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12444248
Plat J and Mensink RP Increased intestinal ABCA1 expression contributes to the decrease in cholesterol absorption after plant stanol consumption. 2002 FASEB J. pmid:12153993
De Graaf J et al. Consumption of tall oil-derived phytosterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels. 2002 Br. J. Nutr. pmid:12425728
Plat J and Mensink RP Effects of diets enriched with two different plant stanol ester mixtures on plasma ubiquinol-10 and fat-soluble antioxidant concentrations. 2001 Metab. Clin. Exp. pmid:11319712
Xu G et al. Plant stanol fatty acid esters inhibit cholesterol absorption and hepatic hydroxymethyl glutaryl coenzyme A reductase activity to reduce plasma levels in rabbits. 2001 Metab. Clin. Exp. pmid:11555847
Normén AL et al. Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on Diet and Cancer. 2001 Am. J. Clin. Nutr. pmid:11451730
Weber N et al. Fatty acid steryl, stanyl, and steroid esters by esterification and transesterification in vacuo using Candida rugosa lipase as catalyst. 2001 J. Agric. Food Chem. pmid:11170561
Condo AM et al. Improved method for the synthesis of trans-feruloyl-beta-sitostanol. 2001 J. Agric. Food Chem. pmid:11600051
Ramjiganesh T et al. The hypocholesterolaemic effects of sitostanol in the guinea pig are in part related to changes in hepatic lipids and lipoprotein composition. 2001 Br. J. Nutr. pmid:11242484
Wasan KM et al. Assessing plasma pharmacokinetics of cholesterol following oral coadministration with a novel vegetable stanol mixture to fasting rats. 2001 J Pharm Sci pmid:11064375
Plat J and Mensink RP Vegetable oil based versus wood based stanol ester mixtures: effects on serum lipids and hemostatic factors in non-hypercholesterolemic subjects. 2000 Atherosclerosis pmid:10580176
Salen G et al. Hyperabsorption and retention of campestanol in a sitosterolemic homozygote: comparison with her mother and three control subjects. 2000 J. Lipid Res. pmid:11060358
Sanders DJ et al. The safety evaluation of phytosterol esters. Part 6. The comparative absorption and tissue distribution of phytosterols in the rat. 2000 Food Chem. Toxicol. pmid:10828500
Hallikainen MA et al. Plant stanol esters affect serum cholesterol concentrations of hypercholesterolemic men and women in a dose-dependent manner. 2000 J. Nutr. pmid:10736328
Normén L et al. Soy sterol esters and beta-sitostanol ester as inhibitors of cholesterol absorption in human small bowel. 2000 Am. J. Clin. Nutr. pmid:10731496
Jones PJ et al. Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. 1999 Am. J. Clin. Nutr. pmid:10357732
Gylling H et al. Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population. 1999 J. Lipid Res. pmid:10191283
Xu G et al. Campestanol (24-methyl-5alpha-cholestan-3beta-ol) absorption and distribution in New Zealand White rabbits: effect of dietary sitostanol. 1999 Metab. Clin. Exp. pmid:10094114
Gylling H and Miettinen TA Cholesterol reduction by different plant stanol mixtures and with variable fat intake. 1999 Metab. Clin. Exp. pmid:10337856
Ostlund RE et al. Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans. 1999 Am. J. Clin. Nutr. pmid:10539742
Hallikainen MA and Uusitupa MI Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects. 1999 Am. J. Clin. Nutr. pmid:10075323
Thompson GR Plant lipids that lower serum cholesterol. 1999 Eur. Heart J. pmid:10529318
Cerrato PL Using designer margarines to control lipid levels. 1999 RN pmid:10578956
Nguyen TT et al. Cholesterol-lowering effect of stanol ester in a US population of mildly hypercholesterolemic men and women: a randomized controlled trial. 1999 Mayo Clin. Proc. pmid:10593347
Robins SJ and Fasulo JM Delineation of a novel hepatic route for the selective transfer of unesterified sterols from high-density lipoproteins to bile: studies using the perfused rat liver. 1999 Hepatology pmid:10216140
Ntanios FY and Jones PJ Dietary sitostanol reciprocally influences cholesterol absorption and biosynthesis in hamsters and rabbits. 1999 Atherosclerosis pmid:10217363
Gylling H et al. Retinol, vitamin D, carotenes and alpha-tocopherol in serum of a moderately hypercholesterolemic population consuming sitostanol ester margarine. 1999 Atherosclerosis pmid:10488954
Ntanios FY et al. Dietary sitostanol reduces plaque formation but not lecithin cholesterol acyl transferase activity in rabbits. 1998 Atherosclerosis pmid:9678775
Ntanios FY and Jones PJ Effects of variable dietary sitostanol concentrations on plasma lipid profile and phytosterol metabolism in hamsters. 1998 Biochim. Biophys. Acta pmid:9487145
Robins SJ and Fasulo JM High density lipoproteins, but not other lipoproteins, provide a vehicle for sterol transport to bile. 1997 J. Clin. Invest. pmid:9022069
Gylling H and Miettinen TA Treatment of lipid disorders in non-insulin-dependent diabetes mellitus. 1997 Curr. Opin. Lipidol. pmid:9412774
Gylling H et al. Reduction of serum cholesterol in postmenopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine: women and dietary sitostanol. 1997 Circulation pmid:9416886
Gylling H and Miettinen TA Effects of inhibiting cholesterol absorption and synthesis on cholesterol and lipoprotein metabolism in hypercholesterolemic non-insulin-dependent diabetic men. 1996 J. Lipid Res. pmid:8864962
Robins SJ et al. Hepatic transport and secretion of unesterified cholesterol in the rat is traced by the plant sterol, sitostanol. 1996 J. Lipid Res. pmid:8820098
Ling WH and Jones PJ Enhanced efficacy of sitostanol-containing versus sitostanol-free phytosterol mixtures in altering lipoprotein cholesterol levels and synthesis in rats. 1995 Atherosclerosis pmid:8770325
Woollett LA et al. Apolipoprotein E competitively inhibits receptor-dependent low density lipoprotein uptake by the liver but has no effect on cholesterol absorption or synthesis in the mouse. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:8618929
Lütjohann D et al. Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: effect of sitostanol treatment. 1995 J. Lipid Res. pmid:7595097
Gylling H and Miettinen TA The effect of cholesterol absorption inhibition on low density lipoprotein cholesterol level. 1995 Atherosclerosis pmid:8801876
Denke MA Lack of efficacy of low-dose sitostanol therapy as an adjunct to a cholesterol-lowering diet in men with moderate hypercholesterolemia. 1995 Am. J. Clin. Nutr. pmid:7840080
Gylling H et al. Sitostanol ester margarine in dietary treatment of children with familial hypercholesterolemia. 1995 J. Lipid Res. pmid:7595101
Pedersen TR Lowering cholesterol with drugs and diet. 1995 N. Engl. J. Med. pmid:7566029
Miettinen TA et al. Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. 1995 N. Engl. J. Med. pmid:7566021
Terry JG et al. Evaluation of the use of beta-sitostanol as a nonabsorbable marker for quantifying cholesterol absorption. 1995 J. Lipid Res. pmid:8576653
Vanhanen HT et al. Serum levels, absorption efficiency, faecal elimination and synthesis of cholesterol during increasing doses of dietary sitostanol esters in hypercholesterolaemic subjects. 1994 Clin. Sci. pmid:8062521
Miettinen TA and Vanhanen H Dietary sitostanol related to absorption, synthesis and serum level of cholesterol in different apolipoprotein E phenotypes. 1994 Atherosclerosis pmid:8003098
Lütjohann D et al. Evaluation of deuterated cholesterol and deuterated sitostanol for measurement of cholesterol absorption in humans. 1993 J. Lipid Res. pmid:8354951
Habiger RG et al. Influence of stigmastanol and stigmastanyl-phosphorylcholine, two plasma cholesterol lowering substances, on synthetic phospholipid membranes. A 2H- and 31P-NMR study. 1992 Biochim. Biophys. Acta pmid:1730022
Vanhanen HT and Miettinen TA Effects of unsaturated and saturated dietary plant sterols on their serum contents. 1992 Clin. Chim. Acta pmid:1521345
Czubayko F et al. A simplified micro-method for quantification of fecal excretion of neutral and acidic sterols for outpatient studies in humans. 1991 J. Lipid Res. pmid:1770305
Heinemann T et al. Effect of low-dose sitostanol on serum cholesterol in patients with hypercholesterolemia. 1986 Atherosclerosis pmid:3768090
Skrede B et al. The presence of 5 alpha-sitostanol in the serum of a patient with phytosterolemia, and its biosynthesis from plant steroids in rats with bile fistula. 1985 Biochim. Biophys. Acta pmid:4041477
Aringer L 15-Hydroxylation of 5 beta-cholestan-3 alpha-ol and 24 alpha-ethyl-5 beta-cholestan-3 alpha-ol in rat liver supernatants (18,000 X g). 1982 J. Biol. Chem. pmid:7142175
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