Cholic acid

Cholic acid is a lipid of Sterol Lipids (ST) class. Cholic acid is associated with abnormalities such as Cholestasis, Intrahepatic Cholestasis, Atherosclerosis, Diabetes and cholesterol gallstones. The involved functions are known as Homeostasis, Enterohepatic Circulation, Proliferation (morphologic abnormality), Process and Cell Proliferation. Cholic acid often locates in Hepatic, Cytoplasmic matrix, Membrane, Protoplasm and Tissue membrane. The associated genes with Cholic acid are CYP27A1 gene, ABCB11 gene, NR5A2 gene, SLC10A2 gene and SLC10A1 gene. The related lipids are ursocholic acid, Steroids, Cholestenes, Cholestanes and cholanic acid.

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Introduction

To understand associated biological information of Cholic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Cholic acid?

Cholic acid is suspected in Cholestasis, Obesity, Intrahepatic Cholestasis, Diabetes, cholesterol gallstones, Liver diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Cholic acid

MeSH term MeSH ID Detail
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Arteriosclerosis D001161 86 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Atherosclerosis D050197 85 associated lipids
Insulin Resistance D007333 99 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Cholic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Cholic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Cholic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Cholic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Cholic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Cholic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Cholic acid

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Authors Title Published Journal PubMed Link
pmid:
Van Den Berg JW et al. Solid phase radioimmunoassay for determination of conjugated cholic acid in serum. 1976 Clin. Chim. Acta pmid:1000848
van Berge Henegouwen GP et al. Sulphated and unsulphated bile acids in serum, bile, and urine of patients with cholestasis. 1976 Gut pmid:1001976
Anwer MS et al. Cholic acid uptake and isolated rat hepatocytes. 1976 Hoppe-Seyler's Z. Physiol. Chem. pmid:1002127
Wu L and Curran JF An allosteric synthetic DNA. 1999 Nucleic Acids Res. pmid:10037814
Fromm H et al. [Alterations of bile acid metabolism during treatment with chenodeoxycholic acid. Studies of the role of the appearance of ursodeoxycholic acid in the dissolution of gallstones (author's transl)]. 1976 Klin. Wochenschr. pmid:1003870
Bruusgaard A et al. Bile acid metabolism after jejunoileal bypass operation for obesity. 1976 Scand. J. Gastroenterol. pmid:1006159
Wang DQ et al. Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis. 1999 Am. J. Physiol. pmid:10070053
Pohl RJ et al. Cytochrome P-450 content and mixed-function oxidase activity in microsomes isolated from mouse skin. 1976 Sep-Oct Drug Metab. Dispos. pmid:10143
Hayakawa S et al. Microbiological degradation of bile acids. The conjugation of a certain cholic acid metabolite with amino acids in Corynebacterium equi. 1976 Biochem. J. pmid:1016254