Trihydroxycoprostane

Trihydroxycoprostane is a lipid of Sterol Lipids (ST) class. The involved functions are known as Uptake, Enterohepatic Circulation, Metabolic Inhibition and Ionization. Trihydroxycoprostane often locates in Hepatic, Entire gastrointestinal tract and Abdominal Cavity. The related lipids are 3,7,12-trihydroxycoprostane, (3beta,5beta,7alpha,12alpha)-isomer, Cholestanes and scymnol.

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Introduction

To understand associated biological information of Trihydroxycoprostane, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Trihydroxycoprostane?

There are no associated biomedical information in the current reference collection.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Trihydroxycoprostane

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Trihydroxycoprostane?

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What functions are associated with Trihydroxycoprostane?


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What lipids are associated with Trihydroxycoprostane?

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What genes are associated with Trihydroxycoprostane?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Trihydroxycoprostane?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Trihydroxycoprostane

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Authors Title Published Journal PubMed Link
Hagey LR et al. Major biliary bile acids of the medaka (Oryzias latipes): 25R- and 25S-epimers of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid. 2010 Zool. Sci. pmid:20608845
Ung CY et al. In silico prediction of pregnane X receptor activators by machine learning approaches. 2007 Mol. Pharmacol. pmid:17003167
Persson KP et al. Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome p450 induction potential of drugs in vivo in humans. 2006 Pharm. Res. pmid:16328606
Mast N et al. Distinct binding of cholesterol and 5beta-cholestane-3alpha,7alpha,12alpha-triol to cytochrome P450 27A1: evidence from modeling and site-directed mutagenesis studies. 2006 Biochemistry pmid:16584175
Krasowski MD et al. Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts. 2005 Mol. Endocrinol. pmid:15718292
Dussault I et al. Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12569201
Goodwin B et al. Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12509506
Furster C and Wikvall K Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5beta-cholestane-3alpha,7alpha,12alpha-triol in human liver microsomes. 1999 Biochim. Biophys. Acta pmid:9931427
Suzuki Y [Other peroxisomal diseases]. 1998 Ryoikibetsu Shokogun Shirizu pmid:9645078
Pikuleva IA et al. Expression, purification, and enzymatic properties of recombinant human cytochrome P450c27 (CYP27). 1997 Arch. Biochem. Biophys. pmid:9210654