| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cholestasis | D002779 | 23 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
Total
2
7alpha-Hydroxy-4-cholesten-3-one
7alpha-hydroxy-4-cholesten-3-one is a lipid of Sterol Lipids (ST) class. The related lipids are Steroids and Cholestenones.
Cross Reference
Introduction
To understand associated biological information of 7alpha-Hydroxy-4-cholesten-3-one, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 7alpha-Hydroxy-4-cholesten-3-one?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 7alpha-Hydroxy-4-cholesten-3-one
PubChem Associated disorders and diseases
What pathways are associated with 7alpha-Hydroxy-4-cholesten-3-one
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 7alpha-Hydroxy-4-cholesten-3-one?
There are no associated biomedical information in the current reference collection.
What functions are associated with 7alpha-Hydroxy-4-cholesten-3-one?
There are no associated biomedical information in the current reference collection.
What lipids are associated with 7alpha-Hydroxy-4-cholesten-3-one?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 7alpha-Hydroxy-4-cholesten-3-one?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with 7alpha-Hydroxy-4-cholesten-3-one?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 7alpha-Hydroxy-4-cholesten-3-one
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Donato LJ et al. | Description of analytical method and clinical utility of measuring serum 7-alpha-hydroxy-4-cholesten-3-one (7aC4) by mass spectrometry. | 2018 | Clin. Biochem. | pmid:29051033 |
| Othman RA et al. | Thyroid Hormone Status in Sitosterolemia Is Modified by Ezetimibe. | 2017 | J. Pediatr. | pmid:28625503 |
| Mast N et al. | Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum. | 2017 | J. Biol. Chem. | pmid:28190002 |
| Wang Y et al. | Barley β-glucan reduces blood cholesterol levels via interrupting bile acid metabolism. | 2017 | Br. J. Nutr. | pmid:29115200 |
| Zweers SJ et al. | Prolonged fibroblast growth factor 19 response in patients with primary sclerosing cholangitis after an oral chenodeoxycholic acid challenge. | 2017 | Hepatol Int | pmid:27696157 |
| Mignarri A et al. | Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis. | 2016 | J. Inherit. Metab. Dis. | pmid:26153518 |
| Blahová T et al. | The effect of colesevelam treatment on bile acid and lipid metabolism and glycemic control in healthy men. | 2016 | Physiol Res | pmid:27539104 |
| Zhang L et al. | Impaired Bile Acid Homeostasis in Children with Severe Acute Malnutrition. | 2016 | PLoS ONE | pmid:27163928 |
| Vlachova M et al. | Diurnal variation in cholesterol 7α-hydroxylase activity is determined by the -203A>C polymorphism of the CYP7A1 gene. | 2016 | Croat. Med. J. | pmid:27106353 |
| Graffner H et al. | The ileal bile acid transporter inhibitor A4250 decreases serum bile acids by interrupting the enterohepatic circulation. | 2016 | Aliment. Pharmacol. Ther. | pmid:26527417 |
| Chen M et al. | The rate-determining steps of aldo-keto reductases (AKRs), a study on human steroid 5β-reductase (AKR1D1). | 2015 | Chem. Biol. Interact. | pmid:25500266 |
| Rudling M et al. | Specific inhibition of bile acid transport alters plasma lipids and GLP-1. | 2015 | BMC Cardiovasc Disord | pmid:26197999 |
| Camilleri M et al. | Effect of colesevelam on faecal bile acids and bowel functions in diarrhoea-predominant irritable bowel syndrome. | 2015 | Aliment. Pharmacol. Ther. | pmid:25594801 |
| Camilleri M et al. | Genetic variation in GPBAR1 predisposes to quantitative changes in colonic transit and bile acid excretion. | 2014 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:25012842 |
| Vlaardingerbroek H et al. | New generation lipid emulsions prevent PNALD in chronic parenterally fed preterm pigs. | 2014 | J. Lipid Res. | pmid:24478031 |
| Luo J et al. | A nontumorigenic variant of FGF19 treats cholestatic liver diseases. | 2014 | Sci Transl Med | pmid:25080475 |
| Amano Y et al. | Combinational effects of farnesoid X receptor antagonist and statin on plasma lipid levels and low-density lipoprotein clearance in guinea pigs. | 2014 | Life Sci. | pmid:24805868 |
| Bertolotti M et al. | Age-associated alterations in cholesterol homeostasis: evidence from a cross-sectional study in a Northern Italy population. | 2014 | Clin Interv Aging | pmid:24669190 |
| Pattni SS et al. | Fibroblast growth factor 19 in patients with bile acid diarrhoea: a prospective comparison of FGF19 serum assay and SeHCAT retention. | 2013 | Aliment. Pharmacol. Ther. | pmid:23981126 |
| Freudenberg F et al. | Serum 7-alpha-hydroxy-4-cholesten-3-one as a marker for bile acid loss in children. | 2013 | J. Pediatr. | pmid:23968740 |
| Hirsova P et al. | Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2. | 2013 | Toxicology | pmid:23146761 |
| Ogawa S et al. | An efficient synthesis of 7α,12α-dihydroxy-4-cholesten-3-one and its biological precursor 7α-hydroxy-4-cholesten-3-one: Key intermediates in bile acid biosynthesis. | 2013 | Steroids | pmid:23707572 |
| Marschall HU et al. | Combined rifampicin and ursodeoxycholic acid treatment does not amplify rifampicin effects on hepatic detoxification and transport systems in humans. | 2012 | Digestion | pmid:22964716 |
| Xiang X et al. | Gender, but not CYP7A1 or SLCO1B1 polymorphism, affects the fasting plasma concentrations of bile acids in human beings. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:21902813 |
| Wong BS et al. | Increased bile acid biosynthesis is associated with irritable bowel syndrome with diarrhea. | 2012 | Clin. Gastroenterol. Hepatol. | pmid:22610000 |
| Steiner C et al. | Lipoprotein distribution and serum concentrations of 7α-hydroxy-4-cholesten-3-one and bile acids: effects of monogenic disturbances in high-density lipoprotein metabolism. | 2012 | Clin. Sci. | pmid:22010943 |
| Yang Q et al. | Dietary fish oil increases fat absorption and fecal bile acid content without altering bile acid synthesis in 20-d-old weanling rats following massive ileocecal resection. | 2012 | Pediatr. Res. | pmid:22447320 |
| Lundåsen T et al. | Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice. | 2012 | PLoS ONE | pmid:22662222 |
| Li T and Chiang JY | Bile Acid signaling in liver metabolism and diseases. | 2012 | J Lipids | pmid:21991404 |
| Matysik S et al. | Monitoring of 7α-hydroxy-4-cholesten-3-one during therapy of cerebrotendinous xanthomatosis: a case report. | 2011 | Chem. Phys. Lipids | pmid:21679699 |
| Matysik S et al. | Bile acid signaling after an oral glucose tolerance test. | 2011 | Chem. Phys. Lipids | pmid:21679700 |
| Steiner C et al. | Bile acid metabolites in serum: intraindividual variation and associations with coronary heart disease, metabolic syndrome and diabetes mellitus. | 2011 | PLoS ONE | pmid:22110577 |
| Gälman C et al. | Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19. | 2011 | J. Intern. Med. | pmid:22003820 |
| Wong BS et al. | Effects of A3309, an ileal bile acid transporter inhibitor, on colonic transit and symptoms in females with functional constipation. | 2011 | Am. J. Gastroenterol. | pmid:21876564 |
| Johnston I et al. | New insights into bile acid malabsorption. | 2011 | Curr Gastroenterol Rep | pmid:21805078 |
| Barbara G et al. | The immune system in irritable bowel syndrome. | 2011 | J Neurogastroenterol Motil | pmid:22148103 |
| Brydon WG et al. | An evaluation of the use of serum 7-alpha-hydroxycholestenone as a diagnostic test of bile acid malabsorption causing watery diarrhea. | 2011 | Can. J. Gastroenterol. | pmid:21766092 |
| Mindnich R et al. | The effect of disease associated point mutations on 5β-reductase (AKR1D1) enzyme function. | 2011 | Chem. Biol. Interact. | pmid:21185810 |
| Lenicek M et al. | Bile acid malabsorption in inflammatory bowel disease: assessment by serum markers. | 2011 | Inflamm. Bowel Dis. | pmid:21058331 |
| Kaddurah-Daouk R et al. | Enteric microbiome metabolites correlate with response to simvastatin treatment. | 2011 | PLoS ONE | pmid:22022402 |
| Rao AS et al. | Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis. | 2010 | Gastroenterology | pmid:20691689 |
| Steiner C et al. | Quantification of the 15 major human bile acids and their precursor 7α-hydroxy-4-cholesten-3-one in serum by liquid chromatography-tandem mass spectrometry. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:20869337 |
| Walters JR | Defining primary bile acid diarrhea: making the diagnosis and recognizing the disorder. | 2010 | Expert Rev Gastroenterol Hepatol | pmid:20932141 |
| DeBarber AE et al. | ESI-MS/MS quantification of 7alpha-hydroxy-4-cholesten-3-one facilitates rapid, convenient diagnostic testing for cerebrotendinous xanthomatosis. | 2010 | Clin. Chim. Acta | pmid:19808031 |
| Schreuder TC et al. | The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20093562 |
| Odunsi-Shiyanbade ST et al. | Effects of chenodeoxycholate and a bile acid sequestrant, colesevelam, on intestinal transit and bowel function. | 2010 | Clin. Gastroenterol. Hepatol. | pmid:19879973 |
| Björkhem I and Hansson M | Cerebrotendinous xanthomatosis: an inborn error in bile acid synthesis with defined mutations but still a challenge. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20494109 |
| BÃ¥vner A et al. | On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase. | 2010 | J. Lipid Res. | pmid:20511491 |
| Kovár J et al. | Regulation of diurnal variation of cholesterol 7alpha-hydroxylase (CYP7A1) activity in healthy subjects. | 2010 | Physiol Res | pmid:19537927 |
| Drury JE et al. | Characterization of disease-related 5beta-reductase (AKR1D1) mutations reveals their potential to cause bile acid deficiency. | 2010 | J. Biol. Chem. | pmid:20522910 |
| Xiang X et al. | Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans. | 2009 | Pharmacogenet. Genomics | pmid:19387419 |
| Camilleri M et al. | Measurement of serum 7alpha-hydroxy-4-cholesten-3-one (or 7alphaC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tandem mass spectrometry. | 2009 | Neurogastroenterol. Motil. | pmid:19368662 |
| Walters JR et al. | A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis. | 2009 | Clin. Gastroenterol. Hepatol. | pmid:19426836 |
| Ung KA et al. | Biliary sphincterotomy does not relate to diarrhoea or major changes in bile acid synthesis or plasma lipids. | 2009 | Scand. J. Gastroenterol. | pmid:19811340 |
| Herrera J et al. | Fecal bile acid excretion and messenger RNA expression levels of ileal transporters in high risk gallstone patients. | 2009 | Lipids Health Dis | pmid:19995447 |
| Jiang ZY et al. | Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19071091 |
| Bertolotti M et al. | Correlation between plasma levels of 7alpha-hydroxy-4-cholesten-3-one and cholesterol 7alpha-hydroxylation rates in vivo in hyperlipidemic patients. | 2008 | Steroids | pmid:18582481 |
| Lenicek M et al. | Improved HPLC analysis of serum 7alpha-hydroxycholest-4-en-3-one, a marker of bile acid malabsorption. | 2008 | Clin. Chem. | pmid:18509016 |
| LenÃcek M et al. | CYP7A1 promoter polymorphism -203A>C affects bile salt synthesis rate in patients after ileal resection. | 2008 | J. Lipid Res. | pmid:18728290 |
| Faucher F et al. | The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism. | 2008 | Biochemistry | pmid:18624455 |
| Dawes LG et al. | Decreased bile acid synthesis with total parenteral nutrition. | 2007 | Am. J. Surg. | pmid:17936424 |
| Bertolotti M et al. | Age-related changes in bile acid synthesis and hepatic nuclear receptor expression. | 2007 | Eur. J. Clin. Invest. | pmid:17537158 |
| Ellegård L and Andersson H | Oat bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study. | 2007 | Eur J Clin Nutr | pmid:17251929 |
| Honda A et al. | Highly sensitive quantification of 7alpha-hydroxy-4-cholesten-3-one in human serum by LC-ESI-MS/MS. | 2007 | J. Lipid Res. | pmid:17093295 |
| Lövgren-Sandblom A et al. | Novel LC-MS/MS method for assay of 7alpha-hydroxy-4-cholesten-3-one in human plasma. Evidence for a significant extrahepatic metabolism. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17561450 |
| Ung CY et al. | In silico prediction of pregnane X receptor activators by machine learning approaches. | 2007 | Mol. Pharmacol. | pmid:17003167 |
| Panzenboeck U et al. | On the mechanism of cerebral accumulation of cholestanol in patients with cerebrotendinous xanthomatosis. | 2007 | J. Lipid Res. | pmid:17325385 |
| Castro J et al. | Increased activity of hepatic microsomal triglyceride transfer protein and bile acid synthesis in gallstone disease. | 2007 | Hepatology | pmid:17464999 |
| Bajor A et al. | Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorption. | 2006 | Eur J Gastroenterol Hepatol | pmid:16538111 |
| Klass DM et al. | Biliary lipids, cholesterol and bile synthesis: different adaptive mechanisms to dietary cholesterol in lean and obese subjects. | 2006 | Aliment. Pharmacol. Ther. | pmid:16573792 |
| Montagnani M et al. | Analysis of ileal sodium/bile acid cotransporter and related nuclear receptor genes in a family with multiple cases of idiopathic bile acid malabsorption. | 2006 | World J. Gastroenterol. | pmid:17171805 |
| Bajor A et al. | Budesonide treatment is associated with increased bile acid absorption in collagenous colitis. | 2006 | Aliment. Pharmacol. Ther. | pmid:17094773 |
| Bertolotti M et al. | Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis. | 2006 | Eur. J. Clin. Invest. | pmid:16506961 |
| Maeda Y et al. | Species differences among various rodents in the conversion of 7alpha-hydroxycholesterol in liver microsomes. | 2006 | Steroids | pmid:16455124 |
| Matasconi M et al. | Pituitary control of cholesterol metabolism in normal and LDL receptor knock-out mice: effects of hypophysectomy and growth hormone treatment. | 2005 | Biochim. Biophys. Acta | pmid:16185916 |
| Boekschoten MV et al. | Coffee oil consumption increases plasma levels of 7alpha-hydroxy-4-cholesten-3-one in humans. | 2005 | J. Nutr. | pmid:15795435 |
| O'Neill FH et al. | Comparison of efficacy of plant stanol ester and sterol ester: short-term and longer-term studies. | 2005 | Am. J. Cardiol. | pmid:15992513 |
| Abrahamsson A et al. | Common polymorphisms in the CYP7A1 gene do not contribute to variation in rates of bile acid synthesis and plasma LDL cholesterol concentration. | 2005 | Atherosclerosis | pmid:16115473 |
| Gälman C et al. | Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis. | 2005 | Gastroenterology | pmid:16285946 |
| Ellegård L et al. | High serum phytosterol levels in short bowel patients on parenteral nutrition support. | 2005 | Clin Nutr | pmid:15896428 |
| Ellegård L et al. | Rapeseed oil, olive oil, plant sterols, and cholesterol metabolism: an ileostomy study. | 2005 | Eur J Clin Nutr | pmid:16091765 |
| Honda A et al. | Disrupted coordinate regulation of farnesoid X receptor target genes in a patient with cerebrotendinous xanthomatosis. | 2005 | J. Lipid Res. | pmid:15576845 |
| Marschall HU et al. | Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans. | 2005 | Gastroenterology | pmid:16083704 |
| Gälman C et al. | Bile acid synthesis is increased in Chilean Hispanics with gallstones and in gallstone high-risk Mapuche Indians. | 2004 | Gastroenterology | pmid:14988828 |
| Weinbrenner T et al. | Lipoprotein metabolism in patients with anorexia nervosa: a case-control study investigating the mechanisms leading to hypercholesterolaemia. | 2004 | Br. J. Nutr. | pmid:15182399 |
| Lind S et al. | Growth hormone induces low-density lipoprotein clearance but not bile acid synthesis in humans. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14656733 |
| Honda A et al. | Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits. | 2004 | Metab. Clin. Exp. | pmid:14681840 |
| Sauter GH et al. | Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects. | 2004 | Digestion | pmid:15375335 |
| Dussault I et al. | Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12569201 |
| Ota Y et al. | Assay method for mitochondrial sterol 27-hydroxylase with 7alpha-hydroxy-4-cholesten-3-one as a substrate in the rat liver. | 2003 | J. Lipid Res. | pmid:12951370 |
| Gälman C et al. | Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood. | 2003 | J. Lipid Res. | pmid:12562858 |
| Hosseinpour F et al. | 25-Hydroxylation of vitamin D3 in primary cultures of pig hepatocytes: evidence for a role of both CYP2D25 and CYP27A1. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12670492 |
| Yoshida T et al. | Origin of oxysterols in hepatic bile of patients with biliary infection. | 2003 | Am. J. Gastroenterol. | pmid:14572579 |
| Andersson M et al. | Oat bran stimulates bile acid synthesis within 8 h as measured by 7alpha-hydroxy-4-cholesten-3-one. | 2002 | Am. J. Clin. Nutr. | pmid:12399287 |
| Maeda Y et al. | A comparative study of the conversion of 7-hydroxycholesterol in rabbit, guinea pig, rat, hamster, and chicken. | 2002 | Steroids | pmid:12117617 |
| Gälman C et al. | Prolonged stimulation of the adrenals by corticotropin suppresses hepatic low-density lipoprotein and high-density lipoprotein receptors and increases plasma cholesterol. | 2002 | Endocrinology | pmid:11956163 |
| Matsuzaki Y et al. | Selective inhibition of CYP27A1 and of chenodeoxycholic acid synthesis in cholestatic hamster liver. | 2002 | Biochim. Biophys. Acta | pmid:12385778 |
| Honda A et al. | Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27(-/-) mice and CTX. | 2001 | J. Lipid Res. | pmid:11181760 |
| O'Neill FH et al. | Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11348882 |
| Tatidis L et al. | Cholesterol catabolism in patients with acute myelogenous leukemia and hypocholesterolemia: suppressed levels of a circulating marker for bile acid synthesis. | 2001 | Cancer Lett. | pmid:11463495 |