| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cholestasis | D002779 | 23 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
Total
2
7alpha-Hydroxy-4-cholesten-3-one
7alpha-hydroxy-4-cholesten-3-one is a lipid of Sterol Lipids (ST) class. The related lipids are Steroids and Cholestenones.
Cross Reference
Introduction
To understand associated biological information of 7alpha-Hydroxy-4-cholesten-3-one, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 7alpha-Hydroxy-4-cholesten-3-one?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 7alpha-Hydroxy-4-cholesten-3-one
PubChem Associated disorders and diseases
What pathways are associated with 7alpha-Hydroxy-4-cholesten-3-one
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 7alpha-Hydroxy-4-cholesten-3-one?
There are no associated biomedical information in the current reference collection.
What functions are associated with 7alpha-Hydroxy-4-cholesten-3-one?
There are no associated biomedical information in the current reference collection.
What lipids are associated with 7alpha-Hydroxy-4-cholesten-3-one?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 7alpha-Hydroxy-4-cholesten-3-one?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with 7alpha-Hydroxy-4-cholesten-3-one?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 7alpha-Hydroxy-4-cholesten-3-one
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:19075558 | ||||
| pmid:28378364 | ||||
| pmid:12135027 | ||||
| pmid:28915417 | ||||
| pmid:28039331 | ||||
| pmid:27598558 | ||||
| pmid:26948941 | ||||
| pmid:25820074 | ||||
| pmid:25070056 | ||||
| pmid:24666974 | ||||
| pmid:27855505 | ||||
| pmid:24853400 | ||||
| pmid:27428727 | ||||
| pmid: | ||||
| Pattni SS et al. | Fibroblast growth factor 19 in patients with bile acid diarrhoea: a prospective comparison of FGF19 serum assay and SeHCAT retention. | 2013 | Aliment. Pharmacol. Ther. | pmid:23981126 |
| Klass DM et al. | Biliary lipids, cholesterol and bile synthesis: different adaptive mechanisms to dietary cholesterol in lean and obese subjects. | 2006 | Aliment. Pharmacol. Ther. | pmid:16573792 |
| Bajor A et al. | Budesonide treatment is associated with increased bile acid absorption in collagenous colitis. | 2006 | Aliment. Pharmacol. Ther. | pmid:17094773 |
| Camilleri M et al. | Effect of colesevelam on faecal bile acids and bowel functions in diarrhoea-predominant irritable bowel syndrome. | 2015 | Aliment. Pharmacol. Ther. | pmid:25594801 |
| Graffner H et al. | The ileal bile acid transporter inhibitor A4250 decreases serum bile acids by interrupting the enterohepatic circulation. | 2016 | Aliment. Pharmacol. Ther. | pmid:26527417 |
| O'Neill FH et al. | Comparison of efficacy of plant stanol ester and sterol ester: short-term and longer-term studies. | 2005 | Am. J. Cardiol. | pmid:15992513 |
| Andersson M et al. | Oat bran stimulates bile acid synthesis within 8 h as measured by 7alpha-hydroxy-4-cholesten-3-one. | 2002 | Am. J. Clin. Nutr. | pmid:12399287 |
| Wong BS et al. | Effects of A3309, an ileal bile acid transporter inhibitor, on colonic transit and symptoms in females with functional constipation. | 2011 | Am. J. Gastroenterol. | pmid:21876564 |
| Yoshida T et al. | Origin of oxysterols in hepatic bile of patients with biliary infection. | 2003 | Am. J. Gastroenterol. | pmid:14572579 |
| Schreuder TC et al. | The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20093562 |
| Camilleri M et al. | Genetic variation in GPBAR1 predisposes to quantitative changes in colonic transit and bile acid excretion. | 2014 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:25012842 |
| Dawes LG et al. | Decreased bile acid synthesis with total parenteral nutrition. | 2007 | Am. J. Surg. | pmid:17936424 |
| Ogishima T and Okuda K | An improved method for assay of cholesterol 7 alpha-hydroxylase activity. | 1986 | Anal. Biochem. | pmid:3799966 |
| O'Neill FH et al. | Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11348882 |
| Lind S et al. | Growth hormone induces low-density lipoprotein clearance but not bile acid synthesis in humans. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14656733 |
| Abrahamsson A et al. | Common polymorphisms in the CYP7A1 gene do not contribute to variation in rates of bile acid synthesis and plasma LDL cholesterol concentration. | 2005 | Atherosclerosis | pmid:16115473 |
| Xiang X et al. | Gender, but not CYP7A1 or SLCO1B1 polymorphism, affects the fasting plasma concentrations of bile acids in human beings. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:21902813 |
| Hosseinpour F et al. | 25-Hydroxylation of vitamin D3 in primary cultures of pig hepatocytes: evidence for a role of both CYP2D25 and CYP27A1. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12670492 |
| Björkhem I and Hansson M | Cerebrotendinous xanthomatosis: an inborn error in bile acid synthesis with defined mutations but still a challenge. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20494109 |
| Jiang ZY et al. | Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19071091 |
| Bernhardsson C et al. | 12alpha-hydroxylation of 7alpha-hydroxy-4-cholesten-3-one by a reconstituted system from rat liver microsomes. | 1973 | Biochem. Biophys. Res. Commun. | pmid:4148126 |
| Faucher F et al. | The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism. | 2008 | Biochemistry | pmid:18624455 |
| Matasconi M et al. | Pituitary control of cholesterol metabolism in normal and LDL receptor knock-out mice: effects of hypophysectomy and growth hormone treatment. | 2005 | Biochim. Biophys. Acta | pmid:16185916 |
| Andersson U et al. | Rabbit liver contains one major sterol 12alpha-hydroxylase with broad substrate specificity. | 1998 | Biochim. Biophys. Acta | pmid:9461256 |
| Matsuzaki Y et al. | Selective inhibition of CYP27A1 and of chenodeoxycholic acid synthesis in cholestatic hamster liver. | 2002 | Biochim. Biophys. Acta | pmid:12385778 |
| Rudling M et al. | Specific inhibition of bile acid transport alters plasma lipids and GLP-1. | 2015 | BMC Cardiovasc Disord | pmid:26197999 |
| Weinbrenner T et al. | Lipoprotein metabolism in patients with anorexia nervosa: a case-control study investigating the mechanisms leading to hypercholesterolaemia. | 2004 | Br. J. Nutr. | pmid:15182399 |
| Wang Y et al. | Barley β-glucan reduces blood cholesterol levels via interrupting bile acid metabolism. | 2017 | Br. J. Nutr. | pmid:29115200 |
| Brydon WG et al. | An evaluation of the use of serum 7-alpha-hydroxycholestenone as a diagnostic test of bile acid malabsorption causing watery diarrhea. | 2011 | Can. J. Gastroenterol. | pmid:21766092 |
| Tatidis L et al. | Cholesterol catabolism in patients with acute myelogenous leukemia and hypocholesterolemia: suppressed levels of a circulating marker for bile acid synthesis. | 2001 | Cancer Lett. | pmid:11463495 |
| Chen M et al. | The rate-determining steps of aldo-keto reductases (AKRs), a study on human steroid 5β-reductase (AKR1D1). | 2015 | Chem. Biol. Interact. | pmid:25500266 |
| Mindnich R et al. | The effect of disease associated point mutations on 5β-reductase (AKR1D1) enzyme function. | 2011 | Chem. Biol. Interact. | pmid:21185810 |
| Matysik S et al. | Monitoring of 7α-hydroxy-4-cholesten-3-one during therapy of cerebrotendinous xanthomatosis: a case report. | 2011 | Chem. Phys. Lipids | pmid:21679699 |
| Matysik S et al. | Bile acid signaling after an oral glucose tolerance test. | 2011 | Chem. Phys. Lipids | pmid:21679700 |
| Bertolotti M et al. | Age-associated alterations in cholesterol homeostasis: evidence from a cross-sectional study in a Northern Italy population. | 2014 | Clin Interv Aging | pmid:24669190 |
| Ellegård L et al. | High serum phytosterol levels in short bowel patients on parenteral nutrition support. | 2005 | Clin Nutr | pmid:15896428 |