(2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

(2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 221 references associated with (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.

Here are additional resources we collected from PubChem and MeSH for (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

MeSH term MeSH ID Detail
Vision Disorders D014786 10 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Pregnancy Complications D011248 19 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Total 5

PubChem Biomolecular Interactions and Pathways

All references with (2r, 3s)-2-hydroxybutane-1,2,3-tricarboxylate;2-hydroxybutane-1,2,3-tricarboxylate;2-methylcitrate

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Authors Title Published Journal PubMed Link
Grimek TL and Escalante-Semerena JC The acnD genes of Shewenella oneidensis and Vibrio cholerae encode a new Fe/S-dependent 2-methylcitrate dehydratase enzyme that requires prpF function in vivo. 2004 J. Bacteriol. pmid:14702315
Palacios S and Escalante-Semerena JC 2-Methylcitrate-dependent activation of the propionate catabolic operon (prpBCDE) of Salmonella enterica by the PrpR protein. 2004 Microbiology (Reading, Engl.) pmid:15528672
Peters H et al. A knock-out mouse model for methylmalonic aciduria resulting in neonatal lethality. 2003 J. Biol. Chem. pmid:14555645
Kölker S et al. Methylmalonic acid, a biochemical hallmark of methylmalonic acidurias but no inhibitor of mitochondrial respiratory chain. 2003 J. Biol. Chem. pmid:12972416
Claes WA et al. Identification of two prpDBC gene clusters in Corynebacterium glutamicum and their involvement in propionate degradation via the 2-methylcitrate cycle. 2002 J. Bacteriol. pmid:11976302
Brämer CO et al. Identification of the 2-methylcitrate pathway involved in the catabolism of propionate in the polyhydroxyalkanoate-producing strain Burkholderia sacchari IPT101(T) and analysis of a mutant accumulating a copolyester with higher 3-hydroxyvalerate content. 2002 Appl. Environ. Microbiol. pmid:11772636
Okun JG et al. Neurodegeneration in methylmalonic aciduria involves inhibition of complex II and the tricarboxylic acid cycle, and synergistically acting excitotoxicity. 2002 J. Biol. Chem. pmid:11847233
Blank L et al. AcnC of Escherichia coli is a 2-methylcitrate dehydratase (PrpD) that can use citrate and isocitrate as substrates. 2002 Microbiology (Reading, Engl.) pmid:11782506
Henning BF et al. Long-term effects of vitamin B(12), folate, and vitamin B(6) supplements in elderly people with normal serum vitamin B(12) concentrations. 2001 Jan-Feb Gerontology pmid:11244289
Horswill AR et al. Studies of propionate toxicity in Salmonella enterica identify 2-methylcitrate as a potent inhibitor of cell growth. 2001 J. Biol. Chem. pmid:11376009

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