MeSH term | MeSH ID | Detail |
---|---|---|
Acute Lung Injury | D055371 | 33 associated lipids |
Tendon Injuries | D013708 | 4 associated lipids |
15-epi-lxa4;15r-lxa4 is a lipid of Fatty Acyls (FA) class. 15-epi-lxa4;15r-lxa4 is associated with abnormalities such as Pneumonia, Septicemia, Cystic Fibrosis, Subarachnoid Hemorrhage and Obesity. The involved functions are known as Protective Agents, Signal Transduction, cytokine biosynthesis, Inflammation and Anabolism. 15-epi-lxa4;15r-lxa4 often locates in Blood, Immune system and Heart tissue. The associated genes with 15-epi-lxa4;15r-lxa4 are IL2 gene, CXCL13 gene and CMKLR1 gene. The related lipids are Steroids. The related experimental models are Knock-out.
To understand associated biological information of 15-epi-lxa4;15r-lxa4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
15-epi-lxa4;15r-lxa4 is suspected in Cystic Fibrosis, Asthma, Chagas Cardiomyopathy, Pneumonia, Septicemia, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 15-epi-lxa4;15r-lxa4
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Anuforo OUU et al. | Natural killer cells play an essential role in resolution of antigen-induced inflammation in mice. | 2018 | Mol. Immunol. | pmid:29112834 |
Muralikumar S et al. | Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. | 2017 | Lipids Health Dis | pmid:28109294 |
Singh A et al. | Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia. | 2017 | J. Leukoc. Biol. | pmid:27630217 |
Reis MB et al. | Lipoxin A4 encapsulated in PLGA microparticles accelerates wound healing of skin ulcers. | 2017 | PLoS ONE | pmid:28753648 |
Yang Y et al. | The effects of different frequency treadmill exercise on lipoxin A4 and articular cartilage degeneration in an experimental model of monosodium iodoacetate-induced osteoarthritis in rats. | 2017 | PLoS ONE | pmid:28594958 |
Shi Y et al. | Lipoxin A4 mitigates experimental autoimmune myocarditis by regulating inflammatory response, NF-κB and PI3K/Akt signaling pathway in mice. | 2017 | Eur Rev Med Pharmacol Sci | pmid:28485793 |
Wu SH et al. | Signal transduction involved in lipoxin A4‑induced protection of tubular epithelial cells against hypoxia/reoxygenation injury. | 2017 | Mol Med Rep | pmid:28259922 |
González-Herrera F et al. | Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy. | 2017 | Antimicrob. Agents Chemother. | pmid:27993857 |
Hodges RR et al. | Lipoxin A4 activates ALX/FPR2 receptor to regulate conjunctival goblet cell secretion. | 2017 | Mucosal Immunol | pmid:27072607 |
Zong L et al. | Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer. | 2016 | Oxid Med Cell Longev | pmid:26649143 |