Ingenol 3-angelate

Ingenol 3-angelate is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 455 references associated with Ingenol 3-angelate in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
Lebwohl M et al. Ingenol mebutate gel for actinic keratosis. 2012 N. Engl. J. Med. pmid:22417254
Fallen RS and Gooderham M Ingenol mebutate: an introduction. 2012 Skin Therapy Lett. pmid:22358305
Lee WY et al. Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta. 2010 J. Biol. Chem. pmid:20472553
Li L et al. The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. 2010 Cancer Res. pmid:20460505
Ghoul A et al. Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. 2009 Cancer Res. pmid:19417139
Benhadji KA et al. Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells. 2008 Br. J. Cancer pmid:19034280
Serova M et al. Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells. 2008 Mol. Cancer Ther. pmid:18413805
Challacombe JM et al. Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate. 2006 J. Immunol. pmid:17114487
Cozzi SJ et al. Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway. 2006 Cancer Res. pmid:17047072
Hampson P et al. PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. 2005 Blood pmid:15845901

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