Ganglioside GM2

Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.

Cross Reference

Introduction

To understand associated biological information of Ganglioside GM2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GM2?

Ganglioside GM2 is suspected in Tay-Sachs Disease, Gangliosidoses GM2, Sandhoff Disease, Neuropathy, Cytomegalovirus Infections, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GM2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ganglioside GM2?

Related references are published most in these journals:

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What functions are associated with Ganglioside GM2?


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What lipids are associated with Ganglioside GM2?

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What genes are associated with Ganglioside GM2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ganglioside GM2?

Disease model

Disease model are used in the study 'Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors.' (Ho CW et al., 2010) and Disease model are used in the study 'Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies.' (Tsuji D et al., 2007).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Ganglioside GM2

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Authors Title Published Journal PubMed Link
Meek D et al. Juvenile progressive dystonia: a new phenotype of GM2 gangliosidosis. 1984 Ann. Neurol. pmid:6430210
Scheideler MA et al. Cell-cycle dependence of a ganglioside glycosyltransferase activity and its inhibition by enkephalin in a neurotumor cell line. 1984 J. Neurochem. pmid:6422000
Fishman PH et al. The role of gangliosides in the interaction of human chorionic gonadotropin and cholera toxin with murine Leydig tumor cells. 1984 J. Biol. Chem. pmid:6330091
Li SC et al. Effect of modification of sialic acid on enzymic hydrolysis of gangliosides GM1 and GM2. 1984 J. Biol. Chem. pmid:6232275
Yu RK et al. Characterization of some minor gangliosides in Tay-Sachs brains. 1983 Brain Res. pmid:6414648
Kniep B et al. Gangliotriaosylceramide (asialo GM2), a glycosphingolipid marker for cell lines derived from patients with Hodgkin's disease. 1983 J. Immunol. pmid:6886427
Conzelmann E et al. Ganglioside GM2 N-acetyl-beta-D-galactosaminidase activity in cultured fibroblasts of late-infantile and adult GM2 gangliosidosis patients and of healthy probands with low hexosaminidase level. 1983 Am. J. Hum. Genet. pmid:6614006
Tai T et al. Ganglioside GM2 as a human tumor antigen (OFA-I-1). 1983 Proc. Natl. Acad. Sci. U.S.A. pmid:6193515
Yusuf HK et al. Ganglioside biosynthesis in Golgi apparatus of rat liver. Stimulation by phosphatidylglycerol and inhibition by tunicamycin. 1983 Eur. J. Biochem. pmid:6861762
Harzer K Assay of the GM2-ganglioside cleaving hexosaminidase activity of skin fibroblasts for GM2-gangliosidoses. 1983 Clin. Chim. Acta pmid:6228344