Capsaicin is a lipid of Fatty Acyls (FA) class. Capsaicin is associated with abnormalities such as Morphologically altered structure. The involved functions are known as inhibitors, Regulation, metaplastic cell transformation, Biochemical Pathway and Uptake. Capsaicin often locates in Tissue fiber, Mucous Membrane, Nerve Endings, group Ia axon and Membrane. The associated genes with Capsaicin are TRPV1 gene, WT-1, MAP1LC3A gene, EIF2S3 gene and SLC33A1 gene. The related experimental models are Transgenic Model.
To understand associated biological information of Capsaicin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Capsaicin is suspected in Morphologically altered structure and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Capsaicin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Tachycardia | D013610 | 7 associated lipids |
| Hypothermia | D007035 | 19 associated lipids |
| Out-of-Hospital Cardiac Arrest | D058687 | 1 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Capsaicin through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Transgenic Model are used in the study 'In vitro hepatic and skin metabolism of capsaicin.' (Chanda S et al., 2008).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hanson SM et al. | Capsaicin interaction with TRPV1 channels in a lipid bilayer: molecular dynamics simulation. | 2015 | Biophys. J. | pmid:25809255 |
| Spaziano G et al. | Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. | 2015 | Biomed Res Int | pmid:25866824 |
| Maher SA et al. | Prostaglandin D2 and the role of the DP1, DP2 and TP receptors in the control of airway reflex events. | 2015 | Eur. Respir. J. | pmid:25323233 |
| Swain J and Kumar Mishra A | Location, Partitioning Behavior, and Interaction of Capsaicin with Lipid Bilayer Membrane: Study Using Its Intrinsic Fluorescence. | 2015 | J Phys Chem B | pmid:26302022 |
| Nam JH and Lee DU | Inhibitory effect of oleanolic acid from the rhizomes of Cyperus rotundus on transient receptor potential vanilloid 1 channel. | 2015 | Planta Med. | pmid:25402944 |
| Borrelli F et al. | Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent. | 2015 | Br. J. Pharmacol. | pmid:25205418 |
| Peng X et al. | Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin. | 2015 | Drug Des Devel Ther | pmid:26345516 |
| Aicher SA et al. | Denervation of the Lacrimal Gland Leads to Corneal Hypoalgesia in a Novel Rat Model of Aqueous Dry Eye Disease. | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:26513503 |
| Fernández-Blanco JA et al. | Enhanced cough reflex in a model of bleomycin-induced lung fibrosis in guinea pigs. | 2015 | Clin. Sci. | pmid:26275723 |
| Khan M et al. | Enhancing Activity of Anticancer Drugs in Multidrug Resistant Tumors by Modulating P-Glycoprotein through Dietary Nutraceuticals. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26514453 |