Nervonic acid is a lipid of Fatty Acyls (FA) class. Nervonic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent and Metabolic syndrome. The involved functions are known as Inflammation, Insulin Resistance and Synthesis. Nervonic acid often locates in peroxisomal part and peroxisome. The associated genes with Nervonic acid are ACOX1 gene, TNF gene and CCL2 gene. The related lipids are nervonic acid, Fatty Acids, Unsaturated, palmitoleic acid and Sphingolipids.
To understand associated biological information of Nervonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Nervonic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Nervonic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Zellweger Syndrome | D015211 | 39 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Premature Birth | D047928 | 6 associated lipids |
| Inert Gas Narcosis | D007222 | 1 associated lipids |
| Cleft Lip | D002971 | 8 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Agazzi ME et al. | In-house validation of an improved sample extraction and clean-up method for GC determination of isomers of nervonic acid in meat products. | 2003 | Anal Bioanal Chem | pmid:12732919 |
| Weidner E and Findley A | Catalase in microsporidian spores before and during discharge. | 2003 | Biol. Bull. | pmid:14583549 |
| Kasai N et al. | Three-dimensional structural model analysis of the binding site of an inhibitor, nervonic acid, of both DNA polymerase beta and HIV-1 reverse transcriptase. | 2002 | J. Biochem. | pmid:12417034 |
| Mizushina Y et al. | Structural homology between DNA binding sites of DNA polymerase beta and DNA topoisomerase II. | 2000 | J. Mol. Biol. | pmid:11090281 |
| Mizushina Y et al. | Mode analysis of binding of fatty acids to mammalian DNA polymerases. | 2000 | Biochim. Biophys. Acta | pmid:10903472 |
| Zhou L et al. | [Determination of nervonic acid in oral tonic by GC]. | 1999 | Se Pu | pmid:12549137 |
| Dadras SS et al. | Implication of hydrogen peroxide generation and apoptosis in the neoplastic transformation of mouse fibroblasts overexpressing peroxisomal fatty acyl-CoA oxidase. | 1998 | Int. J. Oncol. | pmid:9454884 |
| Sandhir R et al. | Localization of nervonic acid beta-oxidation in human and rodent peroxisomes: impaired oxidation in Zellweger syndrome and X-linked adrenoleukodystrophy. | 1998 | J. Lipid Res. | pmid:9799802 |
| Cheng C et al. | Charge-remote fragmentations are energy-dependent processes. | 1998 | J. Am. Soc. Mass Spectrom. | pmid:9692256 |
| Mizushina Y et al. | The inhibitory action of fatty acids on DNA polymerase beta. | 1997 | Biochim. Biophys. Acta | pmid:9367179 |