2-ETHYLHEXANOIC ACID is a lipid of Fatty Acyls (FA) class. The involved functions are known as Steroid biosynthesis, cholesterol metabolic process, cholesterol transport, Cell Proliferation and progesterone biosynthetic process. 2-ethylhexanoic acid often locates in Organelles, Tissue membrane, Mitochondria, Mitochondrial Membranes and Cytoplasm. The associated genes with 2-ETHYLHEXANOIC ACID are steroidogenic acute regulatory protein and SLC27A1 gene. The related lipids are 2-ethylhexanoic acid, Steroids, Hexanols and (22R)-22-hydroxycholesterol.
To understand associated biological information of 2-ETHYLHEXANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with 2-ETHYLHEXANOIC ACID
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Hydrocephalus | D006849 | 6 associated lipids |
| Spinal Dysraphism | D016135 | 1 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pennanen S et al. | The developmental toxicity of 2-ethylhexanoic acid in Wistar rats. | 1992 | Fundam Appl Toxicol | pmid:1426708 |
| Dawson DA | Additive incidence of developmental malformation for Xenopus embryos exposed to a mixture of ten aliphatic carboxylic acids. | 1991 | Teratology | pmid:1771595 |
| Pennanen S et al. | Identification of the main metabolites of 2-ethylhexanoic acid in rat urine using gas chromatography-mass spectrometry. | 1991 | J. Chromatogr. | pmid:1770091 |
| Pennanen S and Manninen A | Distribution of 2-ethylhexanoic acid in mice and rats after an intraperitoneal injection. | 1991 | Pharmacol. Toxicol. | pmid:2008413 |
| Veitch K and Van Hoof F | In vitro effects of eight-carbon fatty acids on oxidations in rat liver mitochondria. | 1990 | Biochem. Pharmacol. | pmid:2242043 |
| Górski T et al. | Gas chromatographic determination of 2-ethylhexanol and 2-ethylhexanoic acid as derivatives suitable for electron-capture and nitrogen-phosphorus detection after single reaction with heptafluorobutyrylimidazole. | 1990 | J. Chromatogr. | pmid:2211902 |
| Hauck RS et al. | Asymmetric synthesis and teratogenic activity of (R)- and (S)-2-ethylhexanoic acid, a metabolite of the plasticizer di-(2-ethylhexyl)phthalate. | 1990 | Life Sci. | pmid:2304384 |
| Pennanen S et al. | Urinary arginine and ornithine in occupational exposure to 2-ethylhexanoic acid. | 1990 | Arch. Toxicol. | pmid:2403293 |
| Kröger S | Gas chromatographic determination of 2-ethylhexanoic acid in urine as its pentafluorobenzyl ester. | 1989 | Analyst | pmid:2633655 |
| Manninen A et al. | 2-Ethylhexanoic acid inhibits urea synthesis and stimulates carnitine acetyltransferase activity in rat liver mitochondria. | 1989 | Arch. Toxicol. | pmid:2730342 |