Epothilone D

Epothilone d is a lipid of Polyketides (PK) class. Epothilone d is associated with abnormalities such as Tauopathies, Neutropenia, Neuropathy and Hematological Disease. The involved functions are known as Mutation, Apoptosis, Mitotic arrest, Cell Growth and Anabolism. Epothilone d often locates in Cytoskeleton, Axon, Cell Wall, Chromosomes and Spindle. The associated genes with epothilone D are SLC33A1 gene, Chromatin, GTF2I gene and HEXA gene.

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Introduction

To understand associated biological information of Epothilone D, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Epothilone D?

Epothilone D is suspected in Tauopathies, Neutropenia, Neuropathy, Hematological Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Epothilone D

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Alzheimer Disease D000544 76 associated lipids
Neuroblastoma D009447 66 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Epothilone D

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Epothilone D?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Epothilone D?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Epothilone D?

There are no associated biomedical information in the current reference collection.

What genes are associated with Epothilone D?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Epothilone D?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Epothilone D

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Per page 10 20 50 100 | Total 82
Authors Title Published Journal PubMed Link
Verrills NM et al. Microtubule alterations and mutations induced by desoxyepothilone B: implications for drug-target interactions. 2003 Chem. Biol. pmid:12890533
Lau J et al. Optimizing the heterologous production of epothilone D in Myxococcus xanthus. 2002 Biotechnol. Bioeng. pmid:11920444
Arslanian RL et al. A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus. 2002 J. Nat. Prod. pmid:12141877
Julien B and Shah S Heterologous expression of epothilone biosynthetic genes in Myxococcus xanthus. 2002 Antimicrob. Agents Chemother. pmid:12183227
Arslanian RL et al. Large-scale isolation and crystallization of epothilone D from Myxococcus xanthus cultures. 2002 J. Nat. Prod. pmid:11975503
Chappell MD et al. Probing the SAR of dEpoB via chemical synthesis: a total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B. 2002 J. Org. Chem. pmid:12398496
Rivkin A et al. Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: correlation of ring size with biological activity in the epothilone series. 2002 J. Org. Chem. pmid:12398497
Lichtner RB et al. Subcellular distribution of epothilones in human tumor cells. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11562452
Hardt IH et al. New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. 2001 J. Nat. Prod. pmid:11473410
Sinha SC et al. Catalytic antibody route to the naturally occurring epothilones: total synthesis of epothilones A-F. 2001 Chemistry pmid:11349910