Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Luo S et al. | An extracytoplasmic function sigma factor, σ(25), differentially regulates avermectin and oligomycin biosynthesis in Streptomyces avermitilis. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24811406 |
| Chen LJ et al. | The effects of avermectin on amino acid neurotransmitters and their receptors in the pigeon brain. | 2014 | Pestic Biochem Physiol | pmid:24759046 |
| Demeler J et al. | Measuring the effect of avermectins and milbemycins on somatic muscle contraction of adult Haemonchus contortus and on motility of Ostertagia circumcincta in vitro. | 2014 | Parasitology | pmid:24576444 |
| Sun P et al. | Effect of stereochemistry of avermectin-like 6,6-spiroketals on biological activities and endogenous biotransformations in Streptomyces avermectinius. | 2014 | Chembiochem | pmid:24573905 |
| Zhuo Y et al. | Synthetic biology of avermectin for production improvement and structure diversification. | 2014 | Biotechnol J | pmid:24478271 |
| Li HB et al. | Combined effects of temperature and avermectins on life history and stress response of the western flower thrips, Frankliniella occidentalis. | 2014 | Pestic Biochem Physiol | pmid:24485314 |
| Liu C et al. | Effects of avermectin on immune function and oxidative stress in the pigeon spleen. | 2014 | Chem. Biol. Interact. | pmid:24412236 |
| Kennedy CJ et al. | Inhibition of P-glycoprotein in the blood-brain barrier alters avermectin neurotoxicity and swimming performance in rainbow trout. | 2014 | Aquat. Toxicol. | pmid:24316435 |
| He F et al. | Engineering of the TetR family transcriptional regulator SAV151 and its target genes increases avermectin production in Streptomyces avermitilis. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24220792 |
| Wang JB et al. | Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain. | 2014 | Biotechnol. Lett. | pmid:24322771 |