Avermectin is a lipid of Polyketides (PK) class. Avermectin is associated with abnormalities such as Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease and Onchocerciasis. The involved functions are known as Anabolism, Binding (Molecular Function), physiological aspects, Saturated and Cell Growth. Avermectin often locates in receptor complex and cell body (neuron). The associated genes with Avermectin are Homologous Gene, Genome, Gene Clusters and Structural gene.
To understand associated biological information of Avermectin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Avermectin is suspected in Parasitic infection, Parasitic Diseases, Scabies, Tropical Disease, Onchocerciasis, Filarial Elephantiases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Avermectin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Trichostrongyloidiasis | D014252 | 7 associated lipids |
| Arteritis | D001167 | 2 associated lipids |
| Filariasis | D005368 | 6 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Trichostrongylosis | D014253 | 5 associated lipids |
| Tuberculosis, Multidrug-Resistant | D018088 | 6 associated lipids |
| Oesophagostomiasis | D009814 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Długońska H | The Nobel Prize 2015 in physiology or medicine for highly effective antiparasitic drugs. | 2015 | Ann Parasitol | pmid:26878630 |
| Boden R | Editorial: on artemisinin, avermectins and Nobel Prizes. | 2015 | FEMS Microbiol. Lett. | pmid:26486159 |
| Owens B | 2015 Nobel Prize goes to antiparasitic drug discoverers. | 2015 | Lancet | pmid:26466031 |
| Agbedanu PN et al. | Doxycycline as an inhibitor of p-glycoprotein in the alpaca for the purpose of maintaining avermectins in the CNS during treatment for parelaphostrongylosis. | 2015 | Vet. Parasitol. | pmid:26371853 |
| Yang R et al. | The PhoP transcription factor negatively regulates avermectin biosynthesis in Streptomyces avermitilis. | 2015 | Appl. Microbiol. Biotechnol. | pmid:26298701 |
| Dalzell AM et al. | Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines. | 2015 | Toxicol. Lett. | pmid:25865432 |
| Li X et al. | Fast and Online Determination of Five Avermectin Residues in Foodstuffs of Plant and Animal Origin Using Reusable Polymeric Monolithic Extractor Coupled with LC-MS/MS. | 2015 | J. Agric. Food Chem. | pmid:25865176 |
| Rúbies A et al. | Determination of avermectins: a QuEChERS approach to the analysis of food samples. | 2015 | Food Chem | pmid:25794721 |
| Li D et al. | Synergistic effect of non-ionic surfactants Tween 80 and PEG6000 on cytotoxicity of insecticides. | 2015 | Environ. Toxicol. Pharmacol. | pmid:25699500 |
| Chen C et al. | The synergistic toxicity of the multiple chemical mixtures: implications for risk assessment in the terrestrial environment. | 2015 | Environ Int | pmid:25667058 |