Cardamonin is a lipid of Polyketides (PK) class. Cardamonin is associated with abnormalities such as Septicemia, endothelial dysfunction, Hypertensive disease, Morphologically altered structure and Disintegration. The involved functions are known as Phosphorylation, Transcriptional Activation, Cell secretion, Canonical Wnt Signaling Pathway and Signal Transduction. Cardamonin often locates in Extracellular, Body tissue, IkappaB kinase complex, Membrane and Muscle, Smooth, Vascular. The associated genes with Cardamonin are ITLN1 gene, Candidate Disease Gene, MTPN gene, Genes, Reporter and PTGS2 gene. The related lipids are Lipopolysaccharides.
To understand associated biological information of Cardamonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cardamonin is suspected in Hypertensive disease, Septicemia, endothelial dysfunction, Morphologically altered structure, Disintegration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cardamonin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Break MKB et al. | Discovery of a highly active anticancer analogue of cardamonin that acts as an inducer of caspase-dependent apoptosis and modulator of the mTOR pathway. | 2018 | Fitoterapia | pmid:29355749 |
| Benchabane S et al. | Cardamonin inhibits pro-inflammatory cytokine production and suppresses NO pathway in PBMCs from patients with primary Sjögren's syndrome. | 2018 | Immunopharmacol Immunotoxicol | pmid:29303022 |
| Shi D et al. | Glycolysis inhibition via mTOR suppression is a key step in cardamonin-induced autophagy in SKOV3 cells. | 2018 | BMC Complement Altern Med | pmid:30514289 |
| You W et al. | Cardamonin protects against adverse cardiac remodeling through mTORC1 inhibition in mice with myocardial infarction. | 2018 | Pharmazie | pmid:30223933 |
| Ping CP et al. | Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPVâ‚, Glutamate, and Opioid Receptors. | 2018 | Molecules | pmid:30177603 |
| Shi D et al. | Autophagy induced by cardamonin is associated with mTORC1 inhibition in SKOV3 cells. | 2018 | Pharmacol Rep | pmid:30099297 |
| Chen H et al. | Anti-inflammatory Effects of Cardamonin in Ovarian Cancer Cells Are Mediated via mTOR Suppression. | 2018 | Planta Med. | pmid:29772587 |
| Peng S et al. | Activation of Nrf2-driven antioxidant enzymes by cardamonin confers neuroprotection of PC12 cells against oxidative damage. | 2017 | Food Funct | pmid:28271112 |
| Xiao H et al. | Biological evaluation of phytoconstituents from Polygonum hydropiper. | 2017 | Nat. Prod. Res. | pmid:28000515 |
| Ali AA et al. | Protective effect of cardamonin against acetic acid-induced ulcerative colitis in rats. | 2017 | Pharmacol Rep | pmid:28129600 |