Cardamonin

Cardamonin is a lipid of Polyketides (PK) class. Cardamonin is associated with abnormalities such as Septicemia, endothelial dysfunction, Hypertensive disease, Morphologically altered structure and Disintegration. The involved functions are known as Phosphorylation, Transcriptional Activation, Cell secretion, Canonical Wnt Signaling Pathway and Signal Transduction. Cardamonin often locates in Extracellular, Body tissue, IkappaB kinase complex, Membrane and Muscle, Smooth, Vascular. The associated genes with Cardamonin are ITLN1 gene, Candidate Disease Gene, MTPN gene, Genes, Reporter and PTGS2 gene. The related lipids are Lipopolysaccharides.

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Introduction

To understand associated biological information of Cardamonin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Cardamonin?

Cardamonin is suspected in Hypertensive disease, Septicemia, endothelial dysfunction, Morphologically altered structure, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Cardamonin

MeSH term MeSH ID Detail
Lung Neoplasms D008175 171 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Insulin Resistance D007333 99 associated lipids
Neoplasm Invasiveness D009361 23 associated lipids
Total 5

PubChem Associated disorders and diseases

What pathways are associated with Cardamonin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Cardamonin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Cardamonin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Cardamonin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Cardamonin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Cardamonin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Cardamonin

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Authors Title Published Journal PubMed Link
Li Y et al. Cardamonin induces ROS-mediated G2/M phase arrest and apoptosis through inhibition of NF-κB pathway in nasopharyngeal carcinoma. 2017 Cell Death Dis pmid:29048425
Zhang J et al. Cardamonin represses proliferation, invasion, and causes apoptosis through the modulation of signal transducer and activator of transcription 3 pathway in prostate cancer. 2017 Apoptosis pmid:27900636
Atef Y et al. Effect of cardamonin on hepatic ischemia reperfusion induced in rats: Role of nitric oxide. 2017 Eur. J. Pharmacol. pmid:28966130
Jaiswal S et al. Preclinical pharmacokinetics and ADME characterization of a novel anticancer chalcone, cardamonin. 2017 Drug Test Anal pmid:27794181
Sambasevam Y et al. Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: Possible involvement of the opioid system. 2017 Eur. J. Pharmacol. pmid:27988285
Voon FL et al. Cardamonin (2',4'-dihydroxy-6'-methoxychalcone) isolated from Boesenbergia rotunda (L.) Mansf. inhibits CFA-induced rheumatoid arthritis in rats. 2017 Eur. J. Pharmacol. pmid:27845065
Shrivastava S et al. Cardamonin, a chalcone, inhibits human triple negative breast cancer cell invasiveness by downregulation of Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition. 2017 Biofactors pmid:27580587
Li W et al. Cardamonin Alleviates Pressure Overload-induced Cardiac Remodeling and Dysfunction Through Inhibition of Oxidative Stress. 2016 J. Cardiovasc. Pharmacol. pmid:27560458
Mi XG et al. Cardamonin inhibited cell viability and tumorigenesis partially through blockade of testes-specific protease 50-mediated nuclear factor-kappaB signaling pathway activation. 2016 Int. J. Biochem. Cell Biol. pmid:26855338
De Spirt S et al. Interplay between the chalcone cardamonin and selenium in the biosynthesis of Nrf2-regulated antioxidant enzymes in intestinal Caco-2 cells. 2016 Free Radic. Biol. Med. pmid:26698667