Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.
To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coenzyme Q10
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| MELAS Syndrome | D017241 | 3 associated lipids |
| Neglected Diseases | D058069 | 3 associated lipids |
| Rare Diseases | D035583 | 2 associated lipids |
| Sciatic Neuropathy | D020426 | 13 associated lipids |
| Proteostasis Deficiencies | D057165 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pereira R et al. | Major regulatory mechanisms involved in sperm motility. | 2017 Jan-Feb | Asian J. Androl. | pmid:26680031 |
| Zaki ME et al. | Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects. | 2017 Jan - Feb | J Pediatr (Rio J) | pmid:27770619 |
| Roese E and Bunjes H | Drug release studies from lipid nanoparticles in physiological media by a new DSC method. | 2017 | J Control Release | pmid:28450207 |
| Li HN et al. | Water-Soluble Coenzyme Q10 Reduces Rotenone-Induced Mitochondrial Fission. | 2017 | Neurochem. Res. | pmid:28190227 |
| Guilbot A et al. | A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study. | 2017 | BMC Complement Altern Med | pmid:28854909 |
| Alehagen U et al. | Increase in insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 after supplementation with selenium and coenzyme Q10. A prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. | 2017 | PLoS ONE | pmid:28609475 |
| Alehagen U et al. | Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. | 2017 | PLoS ONE | pmid:28448590 |
| Ulla A et al. | Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats. | 2017 | BMC Pharmacol Toxicol | pmid:28427467 |
| Ki Y et al. | Effect of Coenzyme Q10 on Radiation Nephropathy in Rats. | 2017 | J. Korean Med. Sci. | pmid:28378548 |
| Mustafa HN et al. | Protective role of CoQ10 or L-carnitine on the integrity of the myocardium in doxorubicin induced toxicity. | 2017 | Tissue Cell | pmid:28410798 |