Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.
To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coenzyme Q10
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| MELAS Syndrome | D017241 | 3 associated lipids |
| Neglected Diseases | D058069 | 3 associated lipids |
| Rare Diseases | D035583 | 2 associated lipids |
| Sciatic Neuropathy | D020426 | 13 associated lipids |
| Proteostasis Deficiencies | D057165 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Emma F et al. | Mitochondrial dysfunction in inherited renal disease and acute kidney injury. | 2016 | Nat Rev Nephrol | pmid:26804019 |
| Fragaki K et al. | Coenzyme Q10 defects may be associated with a deficiency of Q10-independent mitochondrial respiratory chain complexes. | 2016 | Biol. Res. | pmid:26742794 |
| Murad HA | L-Carnitine, but not coenzyme Q10, enhances the anti-osteoporotic effect of atorvastatin in ovariectomized rats. | 2016 | J Zhejiang Univ Sci B | pmid:26739525 |
| Tarry-Adkins JL et al. | Coenzyme Q10 prevents hepatic fibrosis, inflammation, and oxidative stress in a male rat model of poor maternal nutrition and accelerated postnatal growth. | 2016 | Am. J. Clin. Nutr. | pmid:26718412 |
| Tsai HY et al. | Coenzyme Q10 Attenuates High Glucose-Induced Endothelial Progenitor Cell Dysfunction through AMP-Activated Protein Kinase Pathways. | 2016 | J Diabetes Res | pmid:26682233 |
| Kim MK et al. | Fluviicoccus keumensis gen. nov., sp. nov., isolated from freshwater. | 2016 | Int. J. Syst. Evol. Microbiol. | pmid:26498187 |
| Lipovac M et al. | Comparison of the effect of a combination of eight micronutrients versus a standard mono preparation on sperm parameters. | 2016 | Reprod. Biol. Endocrinol. | pmid:27938385 |
| Fischer A et al. | Coenzyme Q10 Status as a Determinant of Muscular Strength in Two Independent Cohorts. | 2016 | PLoS ONE | pmid:27907044 |
| Lopes-Ramos CM et al. | Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease. | 2016 | Braz. J. Med. Biol. Res. | pmid:27878228 |
| Liu HT et al. | Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial. | 2016 | Nutr J | pmid:27716246 |