Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.
To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coenzyme Q10
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| MELAS Syndrome | D017241 | 3 associated lipids |
| Neglected Diseases | D058069 | 3 associated lipids |
| Rare Diseases | D035583 | 2 associated lipids |
| Sciatic Neuropathy | D020426 | 13 associated lipids |
| Proteostasis Deficiencies | D057165 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mao Z et al. | Additive enhancement of wound healing in diabetic mice by low level light and topical CoQ10. | 2016 | Sci Rep | pmid:26830658 |
| Zhang YP et al. | Acute Hypoglycemia Induces Painful Neuropathy and the Treatment of Coenzyme Q10. | 2016 | J Diabetes Res | pmid:26824041 |
| Barca E et al. | Cerebellar ataxia and severe muscle CoQ10 deficiency in a patient with a novel mutation in ADCK3. | 2016 | Clin. Genet. | pmid:26818466 |
| Kasai T et al. | Serum Levels of Coenzyme Q10 in Patients with Multiple System Atrophy. | 2016 | PLoS ONE | pmid:26812605 |
| Emma F et al. | Mitochondrial dysfunction in inherited renal disease and acute kidney injury. | 2016 | Nat Rev Nephrol | pmid:26804019 |
| Asencio C et al. | Severe encephalopathy associated to pyruvate dehydrogenase mutations and unbalanced coenzyme Q10 content. | 2016 | Eur. J. Hum. Genet. | pmid:26014431 |
| Takekawa Y et al. | An Approach to Improve Intestinal Absorption of Poorly Absorbed Water-Insoluble Components via Niemann-Pick C1-Like 1. | 2016 | Biol. Pharm. Bull. | pmid:26934923 |
| Da Y et al. | Successful treatment of periodic paralysis with coenzyme Q10: two case reports. | 2016 | Acta Myol | pmid:28344441 |
| Cullen JK et al. | AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation. | 2016 | PLoS ONE | pmid:26866375 |
| Higashi T et al. | Improvement of Pharmaceutical Properties of Isoprenoid Compounds through the Formation of Cyclodextrin Pseudorotaxane-Like Supramolecules. | 2016 | Chem. Pharm. Bull. | pmid:26852798 |