Coenzyme q10 is a lipid of Prenol Lipids (PR) class. Coenzyme q10 is associated with abnormalities such as Nephrotic Syndrome, Diabetes, COENZYME Q10 DEFICIENCY, Deafness and Hypertensive disease. The involved functions are known as Mutation, Process, Oxidation, Electron Transport and Oxidants. Coenzyme q10 often locates in Mitochondria, soluble, Plasma membrane, Body tissue and Inner mitochondrial membrane. The associated genes with Coenzyme Q10 are MT-CYB gene, ATP5B gene, cytochrome c'', STN gene and NPC1 gene. The related lipids are Total cholesterol and Lipid Peroxides. The related experimental models are Mouse Model.
To understand associated biological information of Coenzyme Q10, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coenzyme Q10 is suspected in Heart failure, Myocardial Ischemia, COENZYME Q10 DEFICIENCY, Neurodegenerative Disorders, Myocardial Infarction, Glaucoma and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coenzyme Q10
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| MELAS Syndrome | D017241 | 3 associated lipids |
| Neglected Diseases | D058069 | 3 associated lipids |
| Rare Diseases | D035583 | 2 associated lipids |
| Sciatic Neuropathy | D020426 | 13 associated lipids |
| Proteostasis Deficiencies | D057165 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.' (Lulli M et al., 2012).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li L et al. | Bombella intestini gen. nov., sp. nov., an acetic acid bacterium isolated from bumble bee crop. | 2015 | Int. J. Syst. Evol. Microbiol. | pmid:25336723 |
| Alehagen U et al. | Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized Double-Blind Placebo-Controlled Trial in Elderly Citizens. | 2015 | PLoS ONE | pmid:26624886 |
| Okeahialam BN | Reversal of statin-induced memory dysfunction by co-enzyme Q10: a case report. | 2015 | Vasc Health Risk Manag | pmid:26604775 |
| Gueven N et al. | Border between natural product and drug: comparison of the related benzoquinones idebenone and coenzyme Q10. | 2015 | Redox Biol | pmid:25625583 |
| Desbats MA et al. | Primary coenzyme Q10 deficiency presenting as fatal neonatal multiorgan failure. | 2015 | Eur. J. Hum. Genet. | pmid:25564041 |
| Dutta A et al. | Hypersensitive response-like lesions 1 codes for AtPPT1 and regulates accumulation of ROS and defense against bacterial pathogen Pseudomonas syringae in Arabidopsis thaliana. | 2015 | Antioxid. Redox Signal. | pmid:25557512 |
| Jing L et al. | Coenzyme Q10 protects astrocytes from ROS-induced damage through inhibition of mitochondria-mediated cell death pathway. | 2015 | Int. J. Biol. Sci. | pmid:25552930 |
| Alehagen U and Aaseth J | Selenium and coenzyme Q10 interrelationship in cardiovascular diseases--A clinician's point of view. | 2015 | J Trace Elem Med Biol | pmid:25511910 |
| Iwasaki M et al. | Comparison of plasma levels of nutrient-related biomarkers among Japanese populations in Tokyo, Japan, São Paulo, Brazil, and Hawaii, USA. | 2015 | Eur. J. Cancer Prev. | pmid:25633435 |
| Fischer T | [Pharmacological therapy of age-related macular degeneration based on etiopathogenesis]. | 2015 | Orv Hetil | pmid:26548469 |