Laurylsphingosine is a lipid of Sphingolipids (SP) class. Laurylsphingosine is associated with abnormalities such as BOSLEY-SALIH-ALORAINY SYNDROME, Obesity and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as ceramide biosynthetic process, Anabolism, Signal, Signal Transduction and Transcriptional Activation. Laurylsphingosine often locates in Protoplasm, Plasma membrane, Epidermis, lamellar body and Stratum corneum. The associated genes with Laurylsphingosine are CFB gene. The related lipids are Nonesterified Fatty Acids, Fatty Acids, Sphingolipids, Palmitates and Stearates.
To understand associated biological information of Laurylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Laurylsphingosine is suspected in Obesity, BOSLEY-SALIH-ALORAINY SYNDROME, Diabetes Mellitus, Non-Insulin-Dependent and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Laurylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Zellweger Syndrome | D015211 | 39 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lew BL et al. | Ceramides and cell signaling molecules in psoriatic epidermis: reduced levels of ceramides, PKC-alpha, and JNK. | 2006 | J. Korean Med. Sci. | pmid:16479073 |
| Park J et al. | Inhibition of interleukin-4 production in activated T cells via the downregulation of AP-1/NF-AT activation by N-lauroyl-D-erythro-sphingosine and N-lauroyl-D-erythro-C20-sphingosine. | 2006 | Biochem. Pharmacol. | pmid:16448625 |
| Chavez JA et al. | Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling. | 2005 | J. Biol. Chem. | pmid:15774472 |
| Klein J | Functions and pathophysiological roles of phospholipase D in the brain. | 2005 | J. Neurochem. | pmid:16042758 |
| Erdreich-Epstein A et al. | Endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 involves ceramide metabolic pathways. | 2005 | Blood | pmid:15705795 |
| Demarchi F et al. | Ceramide triggers an NF-kappaB-dependent survival pathway through calpain. | 2005 | Cell Death Differ. | pmid:15933726 |
| Persaud-Sawin DA and Boustany RM | Cell death pathways in juvenile Batten disease. | 2005 | Apoptosis | pmid:16151633 |
| Saito M et al. | Ethanol-induced changes in the content of triglycerides, ceramides, and glucosylceramides in cultured neurons. | 2005 | Alcohol. Clin. Exp. Res. | pmid:16131844 |
| Pettus BJ et al. | Mass spectrometric analysis of ceramide perturbations in brain and fibroblasts of mice and human patients with peroxisomal disorders. | 2004 | Rapid Commun. Mass Spectrom. | pmid:15282781 |
| Helge JW et al. | Exercise and training effects on ceramide metabolism in human skeletal muscle. | 2004 | Exp. Physiol. | pmid:15109217 |