Laurylsphingosine is a lipid of Sphingolipids (SP) class. Laurylsphingosine is associated with abnormalities such as BOSLEY-SALIH-ALORAINY SYNDROME, Obesity and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as ceramide biosynthetic process, Anabolism, Signal, Signal Transduction and Transcriptional Activation. Laurylsphingosine often locates in Protoplasm, Plasma membrane, Epidermis, lamellar body and Stratum corneum. The associated genes with Laurylsphingosine are CFB gene. The related lipids are Nonesterified Fatty Acids, Fatty Acids, Sphingolipids, Palmitates and Stearates.
To understand associated biological information of Laurylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Laurylsphingosine is suspected in Obesity, BOSLEY-SALIH-ALORAINY SYNDROME, Diabetes Mellitus, Non-Insulin-Dependent and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Laurylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Zellweger Syndrome | D015211 | 39 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ohnishi Y et al. | Ceramidase activity in bacterial skin flora as a possible cause of ceramide deficiency in atopic dermatitis. | 1999 | Clin. Diagn. Lab. Immunol. | pmid:9874672 |
| Di Marzio L et al. | Effect of the lactic acid bacterium Streptococcus thermophilus on ceramide levels in human keratinocytes in vitro and stratum corneum in vivo. | 1999 | J. Invest. Dermatol. | pmid:10417626 |
| Watanabe R et al. | Up-regulation of glucosylceramide synthase expression and activity during human keratinocyte differentiation. | 1998 | J. Biol. Chem. | pmid:9545298 |
| Futerman AH | The roles of ceramide in the regulation of neuronal growth and development. | 1998 | Biochemistry Mosc. | pmid:9526098 |
| Gill JS and Windebank AJ | Suramin induced ceramide accumulation leads to apoptotic cell death in dorsal root ganglion neurons. | 1998 | Cell Death Differ. | pmid:10203686 |
| van Echten-Deckert G et al. | Turnover of endogenous ceramide in cultured normal and Farber fibroblasts. | 1997 | J. Lipid Res. | pmid:9458280 |
| Schäfer A et al. | [Disseminated lipogranulomatosis (Farber disease) with hydrops fetalis]. | 1996 | Pathologe | pmid:8650144 |
| Sando GN et al. | Induction of ceramide glucosyltransferase activity in cultured human keratinocytes. Correlation with culture differentiation. | 1996 | J. Biol. Chem. | pmid:8703011 |
| Ghadially R et al. | The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. | 1995 | J. Clin. Invest. | pmid:7738193 |
| Marchesini S et al. | Sulforhodamine GM1-ganglioside: synthesis and physicochemical properties. | 1994 | Chem. Phys. Lipids | pmid:7954976 |