Laurylsphingosine is a lipid of Sphingolipids (SP) class. Laurylsphingosine is associated with abnormalities such as BOSLEY-SALIH-ALORAINY SYNDROME, Obesity and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as ceramide biosynthetic process, Anabolism, Signal, Signal Transduction and Transcriptional Activation. Laurylsphingosine often locates in Protoplasm, Plasma membrane, Epidermis, lamellar body and Stratum corneum. The associated genes with Laurylsphingosine are CFB gene. The related lipids are Nonesterified Fatty Acids, Fatty Acids, Sphingolipids, Palmitates and Stearates.
To understand associated biological information of Laurylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Laurylsphingosine is suspected in Obesity, BOSLEY-SALIH-ALORAINY SYNDROME, Diabetes Mellitus, Non-Insulin-Dependent and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Laurylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Zellweger Syndrome | D015211 | 39 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Marà M et al. | Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis. | 2004 | J. Clin. Invest. | pmid:15067322 |
| Adams JM et al. | Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. | 2004 | Diabetes | pmid:14693694 |
| Cho Y et al. | An inverse relationship between ceramide synthesis and clinical severity in patients with psoriasis. | 2004 | J. Korean Med. Sci. | pmid:15608398 |
| Guchhait P et al. | Characterization of autoantibodies against sulfatide from a V-gene phage-display library derived from patients with systemic lupus erythematosus. | 2004 | J. Immunol. Methods | pmid:15627618 |
| Malagarie-Cazenave S et al. | Role of FAN in tumor necrosis factor-alpha and lipopolysaccharide-induced interleukin-6 secretion and lethality in D-galactosamine-sensitized mice. | 2004 | J. Biol. Chem. | pmid:14985352 |
| Jana A and Pahan K | Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase. | 2004 | J. Neurosci. | pmid:15509740 |
| Bouwstra JA et al. | Structure of the skin barrier and its modulation by vesicular formulations. | 2003 | Prog. Lipid Res. | pmid:12467638 |
| Humbert P | [Functional consequences of cutaneous lipid perturbation]. | 2003 | Pathol. Biol. | pmid:14567193 |
| Di Marzio L et al. | Effect of the lactic acid bacterium Streptococcus thermophilus on stratum corneum ceramide levels and signs and symptoms of atopic dermatitis patients. | 2003 | Exp. Dermatol. | pmid:14705802 |
| Kirby RJ et al. | Bile salt-stimulated carboxyl ester lipase influences lipoprotein assembly and secretion in intestine: a process mediated via ceramide hydrolysis. | 2002 | J. Biol. Chem. | pmid:11733511 |