DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gallego O et al. | A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. | 2010 | Mol. Syst. Biol. | pmid:21119626 |
| Sheriff DS and Ali EF | Perspective on plasma membrane cholesterol efflux and spermatozoal function. | 2010 | J Hum Reprod Sci | pmid:21209749 |
| Daniels TF et al. | The reverse cholesterol transport pathway improves understanding of genetic networks for fat deposition and muscle growth in beef cattle. | 2010 | PLoS ONE | pmid:21151936 |
| Buffone MG et al. | High cholesterol content and decreased membrane fluidity in human spermatozoa are associated with protein tyrosine phosphorylation and functional deficiencies. | 2009 Sep-Oct | J. Androl. | pmid:19269935 |
| Matthan NR et al. | Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD. | 2009 | J. Lipid Res. | pmid:19436064 |
| Shay CM et al. | Do plant sterol concentrations correlate with coronary artery disease in type 1 diabetes? A report from the Pittsburgh Epidemiology of Diabetes Complications Study. | 2009 | J Diabetes | pmid:20827426 |
| Drzewińska J et al. | [Seladin-1/DHCR24: a key protein of cell homeostasis and cholesterol biosynthesis]. | 2009 | Postepy Hig Med Dosw (Online) | pmid:19597241 |
| Matiz C et al. | Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant? | 2009 | Pediatr Rheumatol Online J | pmid:19814780 |
| Kuehnle K | Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24(-/-) mice. Neurochemical Research (34, 1167-82). | 2009 | Neurochem. Res. | pmid:19475506 |
| Singh P et al. | Differential effects of cholesterol and desmosterol on the ligand binding function of the hippocampal serotonin(1A) receptor: implications in desmosterolosis. | 2009 | Biochim. Biophys. Acta | pmid:19616511 |