| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
Total
2
22-Hydroxycholesterol
22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.
Cross Reference
Introduction
To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 22-Hydroxycholesterol?
22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 22-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 22-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 22-Hydroxycholesterol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 22-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gocze PM and Freeman DA | A cholesteryl ester hydrolase inhibitor blocks cholesterol translocation into the mitochondria of MA-10 Leydig tumor cells. | 1992 | Endocrinology | pmid:1332853 |
| Meikle AW et al. | Extracellular calcium and luteinizing hormone effects on 22-hydroxycholesterol used for testosterone production in mouse Leydig cells. | 1991 Mar-Apr | J. Androl. | pmid:2050582 |
| Mauduit C et al. | Tumor necrosis factor alpha inhibits gonadotropin action in cultured porcine Leydig cells: site(s) of action. | 1991 | Endocrinology | pmid:1659519 |
| Hedger MP and Eddy EM | Leydig cell cooperation in vitro: evidence for communication between adult rat Leydig cells. | 1990 Jan-Feb | J. Androl. | pmid:2155894 |
| Seillan C | Oxysterol mediated changes in fatty acid distribution and lipid synthesis in cultured bovine aortic smooth muscle cells. | 1990 | Lipids | pmid:2110280 |
| Guo H et al. | Interleukin-2 is a potent inhibitor of Leydig cell steroidogenesis. | 1990 | Endocrinology | pmid:2167211 |
| Cupp JR and Vickery LE | Adrenodoxin with a COOH-terminal deletion (des 116-128) exhibits enhanced activity. | 1989 | J. Biol. Chem. | pmid:2912975 |
| Meikle AW et al. | Nonesterified fatty acids modulate steroidogenesis in mouse Leydig cells. | 1989 | Am. J. Physiol. | pmid:2558577 |
| Grochowski D and Szamatowicz M | [The role of gonadotropins, cyclic AMP, 22-R-hydroxycholesterol and cofactors in regulating endocrine functions of the Leydig cells in rats. II. Effects of LH, hCG, dbcAMP, 22-R-OH-cholesterol and cofactors on the synthesis of pregnenolone and testosterone in the interstitial gland of rats]. | 1989 | Ginekol. Pol. | pmid:2561359 |
| Grochowski D and Szamatowicz M | [The role of gonadotropins, cyclic AMP, 22-R-OH-cholesterol and cofactors in regulating endocrine functions of the Leydig cells in rats. III. Mechanisms responsible for "desensitization" of the Leydig cells of rats caused by high doses of hCG]. | 1989 | Ginekol. Pol. | pmid:2561360 |