Dihydrocholesterol is a lipid of Sterol Lipids (ST) class. Dihydrocholesterol is associated with abnormalities such as Exanthema, Morphologically altered structure, protrusion, Dehydration and Xanthoma. The involved functions are known as Regulation, Biochemical Pathway, Methylation, Metabolic Inhibition and Biosynthetic Pathways. Dihydrocholesterol often locates in envelope, Mitochondria, Lipid Bilayers, Host Cell and Membrane. The associated genes with Dihydrocholesterol are GRAP2 gene, PTP4A2 gene, HSD3B7 gene, MBD2 gene and IGF2BP3 gene. The related lipids are Sterols, Cardiolipins, Pregnanes, 7-hydroxy-4-cholesten-3-one and Hydroxycholesterols. The related experimental models are Mouse Model.
To understand associated biological information of Dihydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Dihydrocholesterol is suspected in Xanthoma, Xanthomatosis, Cerebrotendinous, Coronary heart disease, Exanthema, Morphologically altered structure, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Dihydrocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase.' (BÃ¥vner A et al., 2010).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| MOSBACH EH and BEVANS M | Early pathologic and biochemical changes in rabbits fed dihydrocholesterol. | 1960 | Am. J. Pathol. | pmid:13772987 |
| GERSON T | The determination of cholesterol and coprosterol in faecal lipids. | 1960 | Biochem. J. | pmid:13704757 |
| WELLS WW et al. | Lactose diets and cholesterol metabolism. I. Cholesterol absorption, coprostanol formation and bile acid excretion in the rat. | 1960 | J. Nutr. | pmid:13784265 |
| SIERACKI JC et al. | Experimental aortic atherosclerosis in rabbits following the ingestion of dihydrocholesterol. | 1960 | Angiology | pmid:14446526 |
| CHAPMAN DD and CHAIKOFF IL | The manner of absorption of 3-beta-cholestanol and delta 4-cholestenone by the rat. | 1959 | J. Biol. Chem. | pmid:13630893 |
| WELLS WW and COOPER SB | Coprostanol formation. II. The opposing action of dietary lactose and calcium on cholesterol absorption. | 1958 | Arch. Biochem. Biophys. | pmid:13534706 |
| PRANGE I et al. | Bacterial conversion of cholesterol into coprostanol independent of cerebrosides in the medium. | 1958 | Acta Pathol Microbiol Scand | pmid:13508244 |
| BEHER WT et al. | Effect of dihydrocholesterol and beta-sitosterol on cholesterol atherosclerosis in rabbits. | 1957 | Circ. Res. | pmid:13414097 |
| WELLS WW | Coprostanol formation. I. The effect of sodium taurocholate and Tween 80 on the sterol composition of rat feces. | 1957 | Arch. Biochem. Biophys. | pmid:13395541 |
| CHAIKOFF IL et al. | Metabolism of cholestanol. I. Fate of cholestanol-4-C14 in the rat. II. Metabolic interrelations of cholestanol, epicholesterol, and delta4-cholestenone. | 1957 | J. Biol. Chem. | pmid:13398433 |