Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.
To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coprosterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| CLAYTON RB and EDWARDS AM | Conversion of 5-alpha-cholestan-3-beta-ol to delta-7-5-alpha-cholesten-3-beta-ol in cockroaches. | 1963 | J. Biol. Chem. | pmid:14021649 |
| SMITH PF | Fate of ergosterol and cholestanol in pleuro-pneumonia-like organisms. | 1962 | J. Bacteriol. | pmid:13989541 |
| MOSBACH EH and BEVANS M | Early pathologic and biochemical changes in rabbits fed dihydrocholesterol. | 1960 | Am. J. Pathol. | pmid:13772987 |
| GERSON T | The determination of cholesterol and coprosterol in faecal lipids. | 1960 | Biochem. J. | pmid:13704757 |
| WELLS WW et al. | Lactose diets and cholesterol metabolism. I. Cholesterol absorption, coprostanol formation and bile acid excretion in the rat. | 1960 | J. Nutr. | pmid:13784265 |
| SETTY CS and IVY AC | Intestinal absorption of coprostanol (coprosterol) in the rat. | 1960 | Am. J. Physiol. | pmid:13750401 |
| VAHOUNY GV et al. | Comparison of lymphatic absorption of dihydrocholesterol and cholesterol in the rat. | 1960 | Arch. Biochem. Biophys. | pmid:13840683 |
| SIERACKI JC et al. | Experimental aortic atherosclerosis in rabbits following the ingestion of dihydrocholesterol. | 1960 | Angiology | pmid:14446526 |
| CHAPMAN DD and CHAIKOFF IL | The manner of absorption of 3-beta-cholestanol and delta 4-cholestenone by the rat. | 1959 | J. Biol. Chem. | pmid:13630893 |
| WELLS WW and COOPER SB | Coprostanol formation. II. The opposing action of dietary lactose and calcium on cholesterol absorption. | 1958 | Arch. Biochem. Biophys. | pmid:13534706 |