3alpha,12beta-dihydroxy-5alpha-cholan-24-oic acid is a lipid of Sterol Lipids (ST) class. 3alpha,12beta-dihydroxy-5alpha-cholan-24-oic acid is associated with abnormalities such as Cholestasis and Little's Disease. The involved functions are known as inhibitors, Signal Transduction, Phosphorylation, Cell Survival and Detergents. 3alpha,12beta-dihydroxy-5alpha-cholan-24-oic acid often locates in Protoplasm. The related lipids are Promega.
To understand associated biological information of 3alpha,12beta-dihydroxy-5alpha-cholan-24-oic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
3alpha,12beta-dihydroxy-5alpha-cholan-24-oic acid is suspected in Cholestasis, Little's Disease and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 3alpha,12beta-dihydroxy-5alpha-cholan-24-oic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Crohn Disease | D003424 | 12 associated lipids |
| Cholelithiasis | D002769 | 16 associated lipids |
| Blastomycosis | D001759 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Menotti J et al. | A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28865757 |
| Grisin T et al. | Cyclodextrin-mediated self-associating chitosan micro-platelets act as a drug booster against Candida glabrata mucosal infection in immunocompetent mice. | 2017 | Int J Pharm | pmid:28130196 |
| Khattab SN et al. | Study of antileishmanial activity of 2-aminobenzoyl amino acid hydrazides and their quinazoline derivatives. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28087274 |
| Bhari N et al. | Histoplasmosis mimicking non-Hodgkin lymphoma in a 40-year-old man with AIDS. | 2017 | Int J STD AIDS | pmid:27535728 |
| Abdel-Latif MM et al. | Factors regulating nuclear factor-kappa B activation in esophageal cancer cells: Role of bile acids and acid. | 2016 Jan-Mar | J Cancer Res Ther | pmid:27072265 |
| Serafim C et al. | Lipoamino acid-based micelles as promising delivery vehicles for monomeric amphotericin B. | 2016 | Int J Pharm | pmid:26617315 |
| Shen C et al. | Deoxycholic acid (DCA) confers an intestinal phenotype on esophageal squamous epithelium via induction of the stemness-associated reprogramming factors OCT4 and SOX2. | 2016 | Cell Cycle | pmid:27096226 |
| Centuori SM et al. | Deoxycholic acid mediates non-canonical EGFR-MAPK activation through the induction of calcium signaling in colon cancer cells. | 2016 | Biochim. Biophys. Acta | pmid:27086143 |
| Merry M and Boulware DR | Cryptococcal Meningitis Treatment Strategies Affected by the Explosive Cost of Flucytosine in the United States: A Cost-effectiveness Analysis. | 2016 | Clin. Infect. Dis. | pmid:27009249 |
| Surampalli G et al. | Safety evaluation of naringenin upon experimental exposure on rat gastrointestinal epithelium for novel optimal drug delivery. | 2016 | Drug Deliv | pmid:24937377 |