Disease MeSH term: Chemical and Drug Induced Liver Injury

Possible associated with:

Structure name description Reference count
AFBI AFBI is a lipid of Polyketides (PK) class. Afbi is associated with abnormalities such as Pyotraumatic dermatitis, Infection, Hepatitis, Liver diseases and Hepatitis B. The involved functions are known as Immune response, Mutation, Anabolism, Metabolic Inhibition and Increased Sensitivy. Afbi often locates in Body tissue, Hepatic, Cytoplasm, Blood and Micronucleus. The associated genes with AFBI are TP53 gene, Genome, Transgenes, FATE1 gene and MANEA gene. The related lipids are Lipopolysaccharides, Lipid Peroxides, 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole and Liposomes. 5774
(-)-Epigallocatechin gallate (-)-Epigallocatechin gallate is a lipid of Polyketides (PK) class. (-)-epigallocatechin gallate is associated with abnormalities such as IMMUNE SUPPRESSION, Infection, Nodule, Lymphopenia and Tumor Immunity. The involved functions are known as Apoptosis, Cellular Immune Response, Specific immune response, Signal and Infiltration. (-)-epigallocatechin gallate often locates in Immune system, Cytoplasmic Granules, Skin, Protoplasm and Body tissue. The associated genes with (-)-Epigallocatechin gallate are C8orf4 gene, Genes, vpr, MAPK8 gene, P4HTM gene and GAG Gene. The related lipids are Promega, Lipopolysaccharides, Palmitates, Fatty Acids and Sphingolipids. The related experimental models are Mouse Model, Xenograft Model, Transgenic Model, Experimental Autoimmune Encephalomyelitis and Arthritis, Collagen-Induced. 6551
Kolaflavanone Kolaflavanone is a lipid of Polyketides (PK) class. Kolaflavanone is associated with abnormalities such as Diabetes, Hyperglycemia and Diabetic Nephropathy. The involved functions are known as Lipid Peroxidation, cholesterol biosynthetic process, Process, Excretory function and Apoptosis. Kolaflavanone often locates in Renal Tissue and Kidney - Cortex - Glomerulus (MMHCC). The associated genes with Kolaflavanone are Serum Albumin and TNF gene. The related lipids are Total cholesterol. 125
SCHEMBL105486 Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out. 1391
quercetin quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model. 5377
apigenin apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model. 4250
chrysin chrysin is a lipid of Polyketides (PK) class. Chrysin is associated with abnormalities such as Unconjugated hyperbilirubinemia, Metabolic Diseases, Hypogonadism, Renal tubular disorder and Colitis. The involved functions are known as Hypoxia, enzyme activity, Oxidation, inhibitors and Cell Survival. Chrysin often locates in Protoplasm, Plasma membrane, Back, Extracellular and Mitochondria. The associated genes with chrysin are CFB gene, P4HTM gene, UGT1A9 gene, CYP1A1 gene and UGT1A1 gene. The related lipids are Promega, estradiol-3-glucuronide, Steroids and Lipopolysaccharides. The related experimental models are Mouse Model. 1085
Hispidulin Hispidulin is a lipid of Polyketides (PK) class. Hispidulin is associated with abnormalities such as Chagas Disease and Leishmania mexicana disease. The involved functions are known as Metabolic Inhibition. 105
2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone is a lipid of Polyketides (PK) class. 37
naringenin naringenin is a lipid of Polyketides (PK) class. Naringenin is associated with abnormalities such as Dehydration, Papillon-Lefevre Disease, BOSLEY-SALIH-ALORAINY SYNDROME, Cardiovascular Diseases and Atherosclerosis. The involved functions are known as Pigmentation, Biosynthetic Pathways, metaplastic cell transformation, 4-coumarate-CoA ligase activity and Pigment. Naringenin often locates in Body tissue, Cell Wall, Membrane, Cytoplasmic matrix and Tissue membrane. The associated genes with naringenin are Genome, Genes, Regulator, Alleles, Homologous Gene and SPEN gene. The related lipids are Fatty Acids, Total cholesterol, Lipopolysaccharides, Oleates and Cholesterol, Dietary. The related experimental models are Knock-out and Mouse Model. 2420
hesperidin (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 6-O-(6-deoxyhexopyranosyl)hexopyranoside is a lipid of Polyketides (PK) class. (2s)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2h-chromen-7-yl 6-o-(6-deoxyhexopyranosyl)hexopyranoside is associated with abnormalities such as Osteoporosis, Postmenopausal, estrogen deficiency, Chronic venous insufficiency, Neurodegenerative Disorders and Cerebrovascular accident. The involved functions are known as Sweetening Agents, Vmax, enzyme activity, Fermentation and Regulation. (2s)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2h-chromen-7-yl 6-o-(6-deoxyhexopyranosyl)hexopyranoside often locates in Entire gastrointestinal tract, soluble, Entire bony skeleton, Trabecular substance of bone and Blood. The associated genes with (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 6-O-(6-deoxyhexopyranosyl)hexopyranoside are MTPN gene, GLUCOSIDASE, STN gene, SLC33A1 gene and GHRL gene. The related lipids are Total cholesterol and blood lipid. The related experimental models are Arthritis, Collagen-Induced. 1455
emodin emodin is a lipid of Polyketides (PK) class. Emodin is associated with abnormalities such as Infection, Conjunctivitis, Vernal, Stevens-Johnson Syndrome, Conjunctival scar and Allergic Conjunctivitis. The involved functions are known as signaling cascade, Metabolic Inhibition, Cell Death, Phosphorylation and JNK Pathway. Emodin often locates in Membrane, Protoplasm, Mitochondria, Cytoplasmic matrix and soluble. The associated genes with emodin are cytochrome c'', UTS2 gene, TK Gene, Gene Clusters and CFC1 gene. The related lipids are Phosphatidylserines, Promega, Sphingolipids, Membrane Lipids and Palmitates. The related experimental models are Mouse Model and Transgenic Model. 1742
p-Cymene P-cymene is a lipid of Prenol Lipids (PR) class. P-cymene is associated with abnormalities such as Abnormal shape. The involved functions are known as Binding (Molecular Function), inhibitors and Oxidation. P-cymene often locates in Cell membrane. The associated genes with p-Cymene are Chromatin, Homologous Gene and ethylbenzene dehydrogenase. The related lipids are Steroids. 779
1,8-Cineol 1,8-cineol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Amplification, enzyme activity and inhibitors. 1,8-cineol often locates in subsynaptic reticulum. The related lipids are palmitoleic acid, pentadecanoic acid, stearic acid and erucic acid. 1326
Gossypol Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model. 2557
Thapsigargin Thapsigargin is a lipid of Prenol Lipids (PR) class. Thapsigargin is associated with abnormalities such as Impaired glucose tolerance, Obesity and Blood Pressure Disorders. The involved functions are known as Phosphorylation, establishment and maintenance of localization, Regulation, Metabolic Inhibition and Proteolysis. Thapsigargin often locates in Mouse Skin, Cytoplasm, Skin, Protoplasm and Mitochondria. The associated genes with Thapsigargin are ERBB4 gene, F11 gene, CA1 gene, TRNAP1 gene and HSPA5 gene. The related lipids are taurolithocholic acid 3-sulfate, Liposomes, Fatty Acids and stearylamine. The related experimental models are Mouse Model. 8868
Sphingosine 1-phosphate Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis. 2005
fumonisin b1 fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates. 902
cholesterol cholesterol is a lipid of Sterol Lipids (ST) class. Cholesterol is associated with abnormalities such as Trypanosomiasis, Chagas Disease, Cleft Palate, Chondrodysplasia punctata 2, X-linked dominant and Child syndrome. The involved functions are known as Blood Circulation, Sterol Biosynthesis Pathway, Receptor Mediated Endocytosis, Methylation and Signal. Cholesterol often locates in Animal tissue, Blood, Membrane, Plasma membrane and peroxisome. The associated genes with cholesterol are MBD2 gene, SIM, SLC33A1 gene, Genome and NSDHL gene. The related lipids are Sterols, zymosterol, fecosterol, Total cholesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out, Genetically Engineered Mouse and Disease model. 98461
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