Bullatacin is a lipid of Polyketides (PK) class. The involved functions are known as inhibitors, Electron Transport, NADH-ubiquinone oxidoreductase activity, NADH oxidation and Point Mutation. Bullatacin often locates in NADH dehydrogenase complex and Submitochondrial Particles. The associated genes with Bullatacin are NDUFS7 gene, CCL14 wt Allele and TERT gene. The related lipids are Annonaceous Acetogenins.
To understand associated biological information of Bullatacin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Bullatacin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
| Optic Atrophies, Hereditary | D015418 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Morré DJ et al. | Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes. | 1995 | Life Sci. | pmid:7837933 |
| Degli Esposti M et al. | Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I). | 1994 | Biochem. J. | pmid:8037664 |
| Holschneider CH et al. | Bullatacin--in vivo and in vitro experience in an ovarian cancer model. | 1994 | Cancer Chemother. Pharmacol. | pmid:8194168 |
| Zhao GX et al. | Asimin, asiminacin, and asiminecin: novel highly cytotoxic asimicin isomers from Asimina triloba. | 1994 | J. Med. Chem. | pmid:8027979 |
| Ahammadsahib KI et al. | Mode of action of bullatacin: a potent antitumor and pesticidal annonaceous acetogenin. | 1993 | Life Sci. | pmid:8371627 |
| Li XH et al. | Bullatacin, bullatacinone, and squamone, a new bioactive acetogenin, from the bark of Annona squamosa. | 1990 Jan-Feb | J. Nat. Prod. | pmid:2348205 |
| Hui YH et al. | Bullatacin and bullatacinone: two highly potent bioactive acetogenins from Annona bullata. | 1989 May-Jun | J. Nat. Prod. | pmid:2778448 |
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