Bullatacin is a lipid of Polyketides (PK) class. The involved functions are known as inhibitors, Electron Transport, NADH-ubiquinone oxidoreductase activity, NADH oxidation and Point Mutation. Bullatacin often locates in NADH dehydrogenase complex and Submitochondrial Particles. The associated genes with Bullatacin are NDUFS7 gene, CCL14 wt Allele and TERT gene. The related lipids are Annonaceous Acetogenins.
To understand associated biological information of Bullatacin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Bullatacin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
| Optic Atrophies, Hereditary | D015418 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chiu HF et al. | Bullatacin, a potent antitumor Annonaceous acetogenin, induces apoptosis through a reduction of intracellular cAMP and cGMP levels in human hepatoma 2.2.15 cells. | 2003 | Biochem. Pharmacol. | pmid:12527325 |
| Marshall JA et al. | A modular synthesis of annonaceous acetogenins. | 2003 | J. Org. Chem. | pmid:12608790 |
| Royo I et al. | In vitro antitumor SAR of threo/cis/threo/cis/erythro bis-THF acetogenins: correlations with their inhibition of mitochondrial Complex I. | 2003 | Oncol. Res. | pmid:12899242 |
| Chang FR et al. | New adjacent Bis-tetrahydrofuran Annonaceous acetogenins from Annona muricata. | 2003 | Planta Med. | pmid:12677528 |
| González-Coloma A et al. | Selective action of acetogenin mitochondrial complex I inhibitors. | 2002 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:12562089 |
| Jiang S et al. | Mimicry of annonaceous acetogenins: enantioselective synthesis of a (4R)-hydroxy analogue having potent antitumor activity. | 2002 | J. Org. Chem. | pmid:12003552 |
| Xu ZF et al. | [Inhibition of oxygen consumption by annonaceous acetogenins in liver cell respiration and their structure-activity relationship]. | 2002 | Yao Xue Xue Bao | pmid:12567869 |
| Xie BF et al. | [Antitumor effect of anuoning]. | 2002 | Ai Zheng | pmid:12452015 |
| Chih HW et al. | Bullatacin, a potent antitumor annonaceous acetogenin, inhibits proliferation of human hepatocarcinoma cell line 2.2.15 by apoptosis induction. | 2001 | Life Sci. | pmid:11521756 |
| Tormo JR et al. | Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11266168 |