Bullatacin is a lipid of Polyketides (PK) class. The involved functions are known as inhibitors, Electron Transport, NADH-ubiquinone oxidoreductase activity, NADH oxidation and Point Mutation. Bullatacin often locates in NADH dehydrogenase complex and Submitochondrial Particles. The associated genes with Bullatacin are NDUFS7 gene, CCL14 wt Allele and TERT gene. The related lipids are Annonaceous Acetogenins.
To understand associated biological information of Bullatacin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Bullatacin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
| Optic Atrophies, Hereditary | D015418 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nakamaru-Ogiso E et al. | The membrane subunit NuoL(ND5) is involved in the indirect proton pumping mechanism of Escherichia coli complex I. | 2010 | J. Biol. Chem. | pmid:20826797 |
| Kakutani N et al. | Exploring the binding site of delta(lac)-acetogenin in bovine heart mitochondrial NADH-ubiquinone oxidoreductase. | 2010 | Biochemistry | pmid:20459120 |
| Kuete V and Efferth T | Cameroonian medicinal plants: pharmacology and derived natural products. | 2010 | Front Pharmacol | pmid:21833168 |
| Luna-Cazares LM and Gonzalez-Esquinca AR | Susceptibility of complete bacteria and spheroplasts of Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi to rolliniastatin-2. | 2010 | Nat. Prod. Res. | pmid:20582808 |
| Nakamaru-Ogiso E et al. | The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor. | 2010 | FEBS Lett. | pmid:20074573 |
| Pomper KW et al. | Identification of annonaceous acetogenins in the ripe fruit of the North American pawpaw ( Asimina triloba ). | 2009 | J. Agric. Food Chem. | pmid:19711911 |
| Fato R et al. | Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species. | 2009 | Biochim. Biophys. Acta | pmid:19059197 |
| Rodrigues dos Santos Lima LA et al. | Two new adjacent bis-tetrahydrofuran annonaceous acetogenins from seeds of Annona cornifolia. | 2009 | Planta Med. | pmid:19039734 |
| Liang YJ et al. | Bullatacin triggered ABCB1-overexpressing cell apoptosis via the mitochondrial-dependent pathway. | 2009 | J. Biomed. Biotechnol. | pmid:19639048 |
| Sinha SC et al. | Alteration of the bis-tetrahydrofuran core stereochemistries in asimicin can affect the cytotoxicity. | 2008 | J. Med. Chem. | pmid:18975929 |