Bullatacin is a lipid of Polyketides (PK) class. The involved functions are known as inhibitors, Electron Transport, NADH-ubiquinone oxidoreductase activity, NADH oxidation and Point Mutation. Bullatacin often locates in NADH dehydrogenase complex and Submitochondrial Particles. The associated genes with Bullatacin are NDUFS7 gene, CCL14 wt Allele and TERT gene. The related lipids are Annonaceous Acetogenins.
To understand associated biological information of Bullatacin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Bullatacin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Neoplasms, Glandular and Epithelial | D009375 | 12 associated lipids |
| Optic Atrophies, Hereditary | D015418 | 2 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wiart C | Goniothalamus species: a source of drugs for the treatment of cancers and bacterial infections? | 2007 | Evid Based Complement Alternat Med | pmid:17965760 |
| Marshall JA and Sabatini JJ | An outside-in approach to adjacent bistetrahydrofuran annonaceous acetogenins with C2 core symmetry. Total synthesis of asimicin and a C32 analogue. | 2006 | Org. Lett. | pmid:16869659 |
| Zhao H et al. | Advances in Lewis acid controlled carbon-carbon bond-forming reactions enable a concise and convergent total synthesis of bullatacin. | 2006 | Org. Lett. | pmid:16956231 |
| Duval RA et al. | Heterocyclic analogues of squamocin as inhibitors of mitochondrial complex I. On the role of the terminal lactone of annonaceous acetogenins. | 2006 | Biochemistry | pmid:16489765 |
| Makabe H et al. | Synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin, squamostolide, and their inhibitory action with bovine heart mitochondrial complex I. | 2006 | Bioorg. Med. Chem. | pmid:16431114 |
| Tinsley JM and Roush WR | Total synthesis of asimicin via highly stereoselective [3 + 2] annulation reactions of substituted allylsilanes. | 2005 | J. Am. Chem. Soc. | pmid:16076173 |
| Keum G et al. | Stereoselective syntheses of rolliniastatin 1, rollimembrin, and membranacin. | 2005 | J. Am. Chem. Soc. | pmid:16028952 |
| Tinsley JM et al. | Synthesis of (+)-bullatacin via the highly diastereoselective [3+2] annulation reaction of a racemic aldehyde and a nonracemic allylsilane. | 2005 | Org. Lett. | pmid:16146398 |
| Ichimaru N et al. | Synthesis and inhibition mechanism of Delta lac-acetogenins, a novel type of inhibitor of bovine heart mitochondrial complex I. | 2005 | Biochemistry | pmid:15641810 |
| Hamada T et al. | Synthesis and inhibitory action of novel acetogenin mimics with bovine heart mitochondrial complex I. | 2004 | Biochemistry | pmid:15035635 |