Pikromycin

Pikromycin is a lipid of Polyketides (PK) class. The involved functions are known as Anabolism, Process, Cytokinesis, Mutation and Biochemical Pathway. Pikromycin often locates in soluble. The associated genes with Pikromycin are SLC7A1 gene, Homologous Gene, Gene Clusters, Polypeptides and THEMIS gene.

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Introduction

To understand associated biological information of Pikromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Pikromycin?

There are no associated biomedical information in the current reference collection.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Pikromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Pikromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Pikromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Pikromycin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Pikromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Pikromycin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Pikromycin

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Authors Title Published Journal PubMed Link
Hansen DA et al. Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides. 2017 J. Am. Chem. Soc. pmid:28836772
Koch AA et al. A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst. 2017 J. Am. Chem. Soc. pmid:28836768
Pyeon HR et al. Heterologous expression of pikromycin biosynthetic gene cluster using Streptomyces artificial chromosome system. 2017 Microb. Cell Fact. pmid:28569150
Han S et al. Structural insights into the binding of lauric acid to CYP107L2 from Streptomyces avermitilis. 2017 Biochem. Biophys. Res. Commun. pmid:27890614
Goldberg VE et al. Assessment of Erythroid and Granulocytic Hematopoietic Lineages in Patients with Non-Small-Cell Lung Carcinoma. 2017 Bull. Exp. Biol. Med. pmid:28853075
Almutairi MM et al. Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins. 2017 Nucleic Acids Res. pmid:28934499
Tripathi A et al. Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412. 2016 J. Ind. Microbiol. Biotechnol. pmid:27277081
Chemler JA et al. Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination. 2015 J. Am. Chem. Soc. pmid:26230368
Li Y et al. Functional Characterization of a Dehydratase Domain from the Pikromycin Polyketide Synthase. 2015 J. Am. Chem. Soc. pmid:26027428
Hansen DA et al. Substrate controlled divergence in polyketide synthase catalysis. 2015 J. Am. Chem. Soc. pmid:25730816