Epothilone B

Epothilone B is a lipid of Polyketides (PK) class. Epothilone b is associated with abnormalities such as Myelosuppression, Measurable Disease, Neuropathy, Neutropenia and Thrombocytopenia. The involved functions are known as Cell Cycle Arrest, Apoptosis, Signal Transduction, Cytokinesis and Caspase Activation. Epothilone b often locates in Mitochondria, Cytoplasmic matrix, Microtubules, Spindle and Protoplasm. The associated genes with Epothilone B are TNFSF10 gene, DIABLO gene, FADD gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega and Phosphatidylserines. The related experimental models are Xenograft Model and Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Epothilone B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Epothilone B?

Epothilone B is suspected in Peripheral Neuropathy, Myelosuppression, Neuropathy, Morphologically altered structure, Measurable Disease, Neutropenia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Epothilone B

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Adrenal Gland Neoplasms D000310 6 associated lipids
Pheochromocytoma D010673 4 associated lipids
Glioma D005910 112 associated lipids
Uterine Neoplasms D014594 18 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Epothilone B

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Epothilone B?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Epothilone B?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Epothilone B?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Epothilone B?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Epothilone B?

Xenograft Model

Xenograft Model are used in the study 'Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.' (Lin B et al., 2005), Xenograft Model are used in the study 'Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo.' (Hofstetter B et al., 2005) and Xenograft Model are used in the study 'In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models.' (Peterson JK et al., 2005).

Mouse Model

Mouse Model are used in the study 'Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.' (Lin B et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Epothilone B

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Per page 10 20 50 100 | Total 253
Authors Title Published Journal PubMed Link
Rogalska A and Marczak A Nuclear DNA Damage and Repair in Normal Ovarian Cells Caused by Epothilone B. 2015 Asian Pac. J. Cancer Prev. pmid:26434870
Nayak L et al. Multicenter phase 2 study of patupilone for recurrent or progressive brain metastases from non-small cell lung cancer. 2015 Cancer pmid:26308485
Morley S et al. Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes. 2015 Sci Rep pmid:26179371
Ruschel J et al. Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. 2015 Science pmid:25765066
Jiménez VA et al. Structural insight into epothilones antitumor activity based on the conformational preferences and tubulin binding modes of epothilones A and B obtained from molecular dynamics simulations. 2015 J. Biomol. Struct. Dyn. pmid:24773261
Nicolaou KC et al. Synthesis and Biological Evaluation of Novel Epothilone B Side Chain Analogues. 2015 ChemMedChem pmid:26447977
Baumgart T et al. Investigation of epothilone B-induced cell death mechanisms in human epithelial cancer cells -in consideration of combined treatment with ionizing radiation. 2015 Cancer Invest. pmid:25919223
Tran AP and Silver J Neuroscience. Systemically treating spinal cord injury. 2015 Science pmid:25883342
Rogalska A and Marczak A Epothilone B induces human ovarian cancer OV-90 cell apoptosis via external pathway. 2015 Environ. Toxicol. Pharmacol. pmid:25721485
Broggini-Tenzer A et al. Combined treatment strategies for microtubule stabilizing agent-resistant tumors. 2015 J. Natl. Cancer Inst. pmid:25694444