Epothilone B

Epothilone B is a lipid of Polyketides (PK) class. Epothilone b is associated with abnormalities such as Myelosuppression, Measurable Disease, Neuropathy, Neutropenia and Thrombocytopenia. The involved functions are known as Cell Cycle Arrest, Apoptosis, Signal Transduction, Cytokinesis and Caspase Activation. Epothilone b often locates in Mitochondria, Cytoplasmic matrix, Microtubules, Spindle and Protoplasm. The associated genes with Epothilone B are TNFSF10 gene, DIABLO gene, FADD gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega and Phosphatidylserines. The related experimental models are Xenograft Model and Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Epothilone B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Epothilone B?

Epothilone B is suspected in Peripheral Neuropathy, Myelosuppression, Neuropathy, Morphologically altered structure, Measurable Disease, Neutropenia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Epothilone B

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Adrenal Gland Neoplasms D000310 6 associated lipids
Pheochromocytoma D010673 4 associated lipids
Glioma D005910 112 associated lipids
Uterine Neoplasms D014594 18 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Epothilone B

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Epothilone B?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Epothilone B?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Epothilone B?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Epothilone B?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Epothilone B?

Xenograft Model

Xenograft Model are used in the study 'Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.' (Lin B et al., 2005), Xenograft Model are used in the study 'Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo.' (Hofstetter B et al., 2005) and Xenograft Model are used in the study 'In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models.' (Peterson JK et al., 2005).

Mouse Model

Mouse Model are used in the study 'Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.' (Lin B et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Epothilone B

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Per page 10 20 50 100 | Total 253
Authors Title Published Journal PubMed Link
Rogalska A et al. Activation of apoptotic pathway in normal, cancer ovarian cells by epothilone B. 2013 Environ. Toxicol. Pharmacol. pmid:23838010
Moorcraft SY et al. Patupilone in patients with pretreated metastatic/locally recurrent colorectal cancer: results of the Phase II CINATRA trial. 2013 Invest New Drugs pmid:23801302
Scherzinger-Laude K et al. Treatment of neuroblastoma and rhabdomyosarcoma using RGD-modified liposomal formulations of patupilone (EPO906). 2013 Int J Nanomedicine pmid:23818777
Wang C et al. Molybdenum-based complexes with two aryloxides and a pentafluoroimido ligand: catalysts for efficient Z-selective synthesis of a macrocyclic trisubstituted alkene by ring-closing metathesis. 2013 Angew. Chem. Int. Ed. Engl. pmid:23307513
Furmanova-Hollenstein P et al. The microtubule stabilizer patupilone counteracts ionizing radiation-induced matrix metalloproteinase activity and tumor cell invasion. 2013 Radiat Oncol pmid:23631818
Kaiser S et al. From bacteria to antineoplastic: epothilones a successful history. 2013 Anticancer Agents Med Chem pmid:23343081
Roque DM et al. Tubulin-β-III overexpression by uterine serous carcinomas is a marker for poor overall survival after platinum/taxane chemotherapy and sensitivity to epothilones. 2013 Cancer pmid:23585021
Rogalska A et al. Analysis of epothilone B-induced cell death in normal ovarian cells. 2013 Cell Biol. Int. pmid:23955989
Rogalska A et al. Induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone A and B. 2013 Toxicol In Vitro pmid:22995584
Yu D et al. Mechanical and functional properties of epothilone-stabilized microtubules. 2013 Cytoskeleton (Hoboken) pmid:23135951