Epothilone B

Epothilone B is a lipid of Polyketides (PK) class. Epothilone b is associated with abnormalities such as Myelosuppression, Measurable Disease, Neuropathy, Neutropenia and Thrombocytopenia. The involved functions are known as Cell Cycle Arrest, Apoptosis, Signal Transduction, Cytokinesis and Caspase Activation. Epothilone b often locates in Mitochondria, Cytoplasmic matrix, Microtubules, Spindle and Protoplasm. The associated genes with Epothilone B are TNFSF10 gene, DIABLO gene, FADD gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega and Phosphatidylserines. The related experimental models are Xenograft Model and Mouse Model.

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Introduction

To understand associated biological information of Epothilone B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Epothilone B?

Epothilone B is suspected in Peripheral Neuropathy, Myelosuppression, Neuropathy, Morphologically altered structure, Measurable Disease, Neutropenia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Epothilone B

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Adrenal Gland Neoplasms D000310 6 associated lipids
Pheochromocytoma D010673 4 associated lipids
Glioma D005910 112 associated lipids
Uterine Neoplasms D014594 18 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Epothilone B

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Epothilone B?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Epothilone B?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Epothilone B?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Epothilone B?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Epothilone B?

Xenograft Model

Xenograft Model are used in the study 'Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.' (Lin B et al., 2005), Xenograft Model are used in the study 'Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo.' (Hofstetter B et al., 2005) and Xenograft Model are used in the study 'In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models.' (Peterson JK et al., 2005).

Mouse Model

Mouse Model are used in the study 'Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.' (Lin B et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Epothilone B

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Authors Title Published Journal PubMed Link
Jiménez VA et al. Structural insight into epothilones antitumor activity based on the conformational preferences and tubulin binding modes of epothilones A and B obtained from molecular dynamics simulations. 2015 J. Biomol. Struct. Dyn. pmid:24773261
Shen CJ et al. Ionizing radiation induces tumor cell lysyl oxidase secretion. 2014 BMC Cancer pmid:25052686
Suraokar MB et al. Expression profiling stratifies mesothelioma tumors and signifies deregulation of spindle checkpoint pathway and microtubule network with therapeutic implications. 2014 Ann. Oncol. pmid:24669013
Ceresa C et al. Characterization of and protection from neurotoxicity induced by oxaliplatin, bortezomib and epothilone-B. 2014 Anticancer Res. pmid:24403510
Peereboom DM et al. Phase II trial of patupilone in patients with brain metastases from breast cancer. 2014 Neuro-oncology pmid:24470546
Marczak A et al. WP 631 and Epo B synergize in SKOV-3 human ovarian cancer cells. 2014 Environ. Toxicol. Pharmacol. pmid:24374386
Melichar B et al. Intestinal permeability in patients with metastatic colon cancer treated with patupilone. 2014 Clin. Chem. Lab. Med. pmid:24937505
Rogalska A et al. Caspases and ROS - dependent mechanism of action mediated by combination of WP 631 and epothilone B. 2014 Anticancer Agents Med Chem pmid:24913659
Rogalska A et al. Epothilone B induces extrinsic pathway of apoptosis in human SKOV-3 ovarian cancer cells. 2014 Toxicol In Vitro pmid:24583341
Meier V et al. Use of epothilone B (patupilone) in refractory lymphoma and advanced solid tumors in dogs. 2013 Jan-Feb J. Vet. Intern. Med. pmid:23205945