phytosphingosine

phytosphingosine is a lipid of Sphingolipids (SP) class. Phytosphingosine is associated with abnormalities such as Infection, Nodule, Dehydration, Neuropathy and nervous system disorder. The involved functions are known as Saturated, sphingomyelin synthase activity, Heat-Shock Response, Cell Growth and Apoptosis. Phytosphingosine often locates in Clone, Protoplasm, Mitochondria, soluble and Cytoplasmic matrix. The associated genes with phytosphingosine are SGMS1 gene, BCL2 gene, Chromatin, Homologous Gene and DLEU2 gene. The related lipids are Sphingolipids, inositolphosphorylceramide, Phosphatidylserines, dihydroceramide and Fatty Acids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of phytosphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phytosphingosine?

phytosphingosine is suspected in Infection, Nodule, Dehydration, Neuropathy, nervous system disorder, Atopic and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phytosphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phytosphingosine?

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What functions are associated with phytosphingosine?


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What lipids are associated with phytosphingosine?

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What genes are associated with phytosphingosine?

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What common seen animal models are associated with phytosphingosine?

Knock-out

Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001) and Knock-out are used in the study 'SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.' (Brace JL et al., 2007).

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NCBI Entrez Crosslinks

All references with phytosphingosine

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Authors Title Published Journal PubMed Link
Valentijn-Benz M et al. Sphingoid bases inhibit acid-induced demineralization of hydroxyapatite. 2015 Caries Res. pmid:25300299
Han SH et al. Phytosphingosine promotes megakaryocytic differentiation of myeloid leukemia cells. 2015 BMB Rep pmid:26077028
Swinnen E et al. The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. 2014 Mol. Biol. Cell pmid:24196832
Kim BH et al. Phytosphingosine derivatives ameliorate skin inflammation by inhibiting NF-κB and JAK/STAT signaling in keratinocytes and mice. 2014 J. Invest. Dermatol. pmid:24177187
Nagahara Y et al. Loss of Bcl-2 expression correlates with increasing sensitivity to apoptosis in differentiating ES cells. 2014 Cell Biol. Int. pmid:24293136
Di Benedetto R et al. Protected sphingosine from phytosphingosine as an efficient acceptor in glycosylation reaction. 2014 Org. Lett. pmid:24428384
Crehuet R et al. Mechanistic studies on the intramolecular cyclization of O-tosyl phytosphingosines to jaspines. 2014 Nat Prod Commun pmid:25233579
Wu YF et al. First total synthesis of ganglioside DSG-A possessing neuritogenic activity. 2014 Org. Biomol. Chem. pmid:25338766
Grether-Beck S et al. Topical ceramides neither enhance UVB-induced apoptosis in normal human keratinocytes nor affect viability in UVB-irradiated reconstructed human epidermis. 2014 Exp. Dermatol. pmid:25078364
Kondo N et al. Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids. 2014 Nat Commun pmid:25345524