phytosphingosine

phytosphingosine is a lipid of Sphingolipids (SP) class. Phytosphingosine is associated with abnormalities such as Infection, Nodule, Dehydration, Neuropathy and nervous system disorder. The involved functions are known as Saturated, sphingomyelin synthase activity, Heat-Shock Response, Cell Growth and Apoptosis. Phytosphingosine often locates in Clone, Protoplasm, Mitochondria, soluble and Cytoplasmic matrix. The associated genes with phytosphingosine are SGMS1 gene, BCL2 gene, Chromatin, Homologous Gene and DLEU2 gene. The related lipids are Sphingolipids, inositolphosphorylceramide, Phosphatidylserines, dihydroceramide and Fatty Acids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of phytosphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with phytosphingosine?

phytosphingosine is suspected in Infection, Nodule, Dehydration, Neuropathy, nervous system disorder, Atopic and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with phytosphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with phytosphingosine?

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What functions are associated with phytosphingosine?


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What lipids are associated with phytosphingosine?

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What genes are associated with phytosphingosine?

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What common seen animal models are associated with phytosphingosine?

Knock-out

Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001) and Knock-out are used in the study 'SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.' (Brace JL et al., 2007).

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NCBI Entrez Crosslinks

All references with phytosphingosine

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Authors Title Published Journal PubMed Link
Henry SA et al. Metabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiae. 2012 Genetics pmid:22345606
Fischer CL et al. Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria. 2012 Antimicrob. Agents Chemother. pmid:22155833
Demirkan A et al. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. 2012 PLoS Genet. pmid:22359512
Montefusco DJ et al. Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability. 2012 J. Biol. Chem. pmid:22277656
Young SA et al. Sphingolipid and ceramide homeostasis: potential therapeutic targets. 2012 Biochem Res Int pmid:22400113
Li SF et al. Isolation and functional characterisation of the genes encoding Δ(8)-sphingolipid desaturase from Brassica rapa. 2012 J Genet Genomics pmid:22293117
Chang Y et al. Metabolic profiling based on LC/MS to evaluate unintended effects of transgenic rice with cry1Ac and sck genes. 2012 Plant Mol. Biol. pmid:22271304
Huang X et al. Down-regulating sphingolipid synthesis increases yeast lifespan. 2012 PLoS Genet. pmid:22319457
Guo L et al. Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis. 2012 J. Biol. Chem. pmid:22275366
Schuster A et al. A versatile toolkit for high throughput functional genomics with Trichoderma reesei. 2012 Biotechnol Biofuels pmid:22212435