7alpha-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7alpha-hydroxycholesterol is associated with abnormalities such as Atherosclerosis, Morphologically altered structure, Carotid Atherosclerosis, Myocardial Infarction and Cerebrovascular accident. The involved functions are known as Apoptosis, Cell Growth, Necrosis, Chromosome Condensation and Tissue Adhesions. 7alpha-hydroxycholesterol often locates in Arterial system, Endothelium, Cell Nucleus, Membrane and yolk. The associated genes with 7alpha-Hydroxycholesterol are acetyl-aspartyl-glutamyl-valyl-aspartal, BCL2 gene, OGFR gene, Genome and GAPDH gene. The related lipids are Hydroxycholesterols, 7-ketocholesterol, Ketocholesterols, 20-hydroxycholesterol and 25-hydroxycholesterol.
To understand associated biological information of 7alpha-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7alpha-Hydroxycholesterol is suspected in Kozlowski Celermajer Tink syndrome, Atherosclerosis, Carotid Atherosclerosis, Xanthomatosis, Cerebrotendinous, Keratoconjunctivitis Sicca, Fatty Streak, Arterial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7alpha-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee HS et al. | TNF-alpha activates death pathway in human aorta smooth muscle cell in the presence of 7-ketocholesterol. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15993097 |
| Rho MC et al. | 7-Ketocholesterol predisposes human aorta smooth muscle cells to Fas-mediated death. | 2005 | J. Mol. Cell. Cardiol. | pmid:16198370 |
| Ringseis R and Eder K | Effects of dietary fat and oxidized cholesterol on gene expression in rat liver as assessed by cDNA expression array analysis. | 2005 | Eur J Nutr | pmid:15309417 |
| Mast N et al. | Cholesterol binding to cytochrome P450 7A1, a key enzyme in bile acid biosynthesis. | 2005 | Biochemistry | pmid:15736936 |
| Roussi S et al. | Different apoptotic mechanisms are involved in the antiproliferative effects of 7beta-hydroxysitosterol and 7beta-hydroxycholesterol in human colon cancer cells. | 2005 | Cell Death Differ. | pmid:15550935 |
| Prunet C et al. | Activation of caspase-3-dependent and -independent pathways during 7-ketocholesterol- and 7beta-hydroxycholesterol-induced cell death: a morphological and biochemical study. | 2005 | J. Biochem. Mol. Toxicol. | pmid:16292754 |
| Corradini SG et al. | High preoperative recipient plasma 7beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation. | 2005 | Liver Transpl. | pmid:16258953 |
| Kang KA et al. | Cytotoxic effect of 7beta-hydroxycholesterol on human NCI-H460 lung cancer cells. | 2005 | Biol. Pharm. Bull. | pmid:16079477 |
| Boaz M et al. | Baseline oxysterols and other markers of oxidative stress, inflammation and malnutrition in the vitamin e and intima media thickness progression in end-stage renal disease (VIPER) cohort. | 2005 | Nephron Clin Pract | pmid:15849477 |
| Napolitano M and Bravo E | Lipid metabolism and TNF-alpha secretion in response to dietary sterols in human monocyte derived macrophages. | 2005 | Eur. J. Clin. Invest. | pmid:16101668 |