7alpha-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7alpha-hydroxycholesterol is associated with abnormalities such as Atherosclerosis, Morphologically altered structure, Carotid Atherosclerosis, Myocardial Infarction and Cerebrovascular accident. The involved functions are known as Apoptosis, Cell Growth, Necrosis, Chromosome Condensation and Tissue Adhesions. 7alpha-hydroxycholesterol often locates in Arterial system, Endothelium, Cell Nucleus, Membrane and yolk. The associated genes with 7alpha-Hydroxycholesterol are acetyl-aspartyl-glutamyl-valyl-aspartal, BCL2 gene, OGFR gene, Genome and GAPDH gene. The related lipids are Hydroxycholesterols, 7-ketocholesterol, Ketocholesterols, 20-hydroxycholesterol and 25-hydroxycholesterol.
To understand associated biological information of 7alpha-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7alpha-Hydroxycholesterol is suspected in Kozlowski Celermajer Tink syndrome, Atherosclerosis, Carotid Atherosclerosis, Xanthomatosis, Cerebrotendinous, Keratoconjunctivitis Sicca, Fatty Streak, Arterial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7alpha-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lundåsen T et al. | Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice. | 2012 | PLoS ONE | pmid:22662222 |
| Li W et al. | Cell death induced by 7-oxysterols via lysosomal and mitochondrial pathways is p53-dependent. | 2012 | Free Radic. Biol. Med. | pmid:22985798 |
| Arciello M et al. | Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients. | 2012 | Dig Liver Dis | pmid:22154950 |
| Gamba P et al. | Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. | 2011 | Aging Cell | pmid:21272192 |
| Iborra RT et al. | Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. | 2011 | Lipids Health Dis | pmid:21957962 |
| Li W et al. | Lipid accumulation and lysosomal pathways contribute to dysfunction and apoptosis of human endothelial cells caused by 7-oxysterols. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21621514 |
| Liu C et al. | Oxysterols direct B-cell migration through EBI2. | 2011 | Nature | pmid:21796211 |
| Carvalho JF et al. | Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR. | 2011 | J. Med. Chem. | pmid:21797280 |
| Vestergaard MC et al. | The effect of oxycholesterols on thermo-induced membrane dynamics. | 2011 | Biochim. Biophys. Acta | pmid:21600872 |
| Wong WT et al. | Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. | 2011 | Nutr Metab Cardiovasc Dis | pmid:20005687 |