26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.
To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).
Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nguyen VT et al. | Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. | 2015 | Nat Commun | pmid:26610607 |
| Yin K et al. | Vitamin D Protects Against Atherosclerosis via Regulation of Cholesterol Efflux and Macrophage Polarization in Hypercholesterolemic Swine. | 2015 | Arterioscler. Thromb. Vasc. Biol. | pmid:26381871 |
| Mignarri A et al. | Treatment of SPG5 with cholesterol-lowering drugs. | 2015 | J. Neurol. | pmid:26566916 |
| Raza S et al. | The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells. | 2015 | Mol. Cell. Biochem. | pmid:26350565 |
| Javitt NB | Breast cancer and (25R)-26-hydroxycholesterol. | 2015 | Steroids | pmid:26299212 |
| Kim SM et al. | 27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide. | 2015 | Biochim. Biophys. Acta | pmid:25497142 |
| Kim SM et al. | 27-Oxygenated cholesterol induces expression of CXCL8 in macrophages via NF-κB and CD88. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26086093 |
| Marwarha G and Ghribi O | Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap? | 2015 | Exp. Gerontol. | pmid:25261765 |
| Gargiulo S et al. | Relation between TLR4/NF-κB signaling pathway activation by 27-hydroxycholesterol and 4-hydroxynonenal, and atherosclerotic plaque instability. | 2015 | Aging Cell | pmid:25757594 |
| Novakova L et al. | Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis. | 2015 | J. Neurol. Sci. | pmid:26342940 |