Dihydrocholesterol is a lipid of Sterol Lipids (ST) class. Dihydrocholesterol is associated with abnormalities such as Exanthema, Morphologically altered structure, protrusion, Dehydration and Xanthoma. The involved functions are known as Regulation, Biochemical Pathway, Methylation, Metabolic Inhibition and Biosynthetic Pathways. Dihydrocholesterol often locates in envelope, Mitochondria, Lipid Bilayers, Host Cell and Membrane. The associated genes with Dihydrocholesterol are GRAP2 gene, PTP4A2 gene, HSD3B7 gene, MBD2 gene and IGF2BP3 gene. The related lipids are Sterols, Cardiolipins, Pregnanes, 7-hydroxy-4-cholesten-3-one and Hydroxycholesterols. The related experimental models are Mouse Model.
To understand associated biological information of Dihydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Dihydrocholesterol is suspected in Xanthoma, Xanthomatosis, Cerebrotendinous, Coronary heart disease, Exanthema, Morphologically altered structure, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Dihydrocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase.' (BÃ¥vner A et al., 2010).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| von der Lühe B et al. | Investigation of sterols as potential biomarkers for the detection of pig (S. s. domesticus) decomposition fluid in soils. | 2013 | Forensic Sci. Int. | pmid:23583120 |
| Ginanneschi F et al. | Polyneuropathy in cerebrotendinous xanthomatosis and response to treatment with chenodeoxycholic acid. | 2013 | J. Neurol. | pmid:22878431 |
| Martini G et al. | Long-term bone density evaluation in cerebrotendinous xanthomatosis: evidence of improvement after chenodeoxycholic acid treatment. | 2013 | Calcif. Tissue Int. | pmid:23212544 |
| Osman R et al. | Chemometric application in identifying sources of organic contaminants in Langat river basin. | 2012 | Environ Monit Assess | pmid:21494831 |
| Nochioka K et al. | Ezetimibe improves endothelial function and inhibits Rho-kinase activity associated with inhibition of cholesterol absorption in humans. | 2012 | Circ. J. | pmid:22640986 |
| Rogacev KS et al. | Cholesterol synthesis, cholesterol absorption, and mortality in hemodialysis patients. | 2012 | Clin J Am Soc Nephrol | pmid:22461539 |
| Lahti M and Oikari A | Vertical distribution of pharmaceuticals in lake sediments-citalopram as potential chemomarker. | 2012 | Environ. Toxicol. Chem. | pmid:22639393 |
| Suh S et al. | Three siblings with Cerebrotendinous Xanthomatosis: a novel mutation in the CYP27A1 gene. | 2012 | Eur J Med Genet | pmid:21958693 |
| Koyama S et al. | A case of cerebrotendinous xanthomatosis presenting with epilepsy as an initial symptom with a novel V413D mutation in the CYP27A1 gene. | 2012 | Clin Neurol Neurosurg | pmid:22336472 |
| Derrien M et al. | Origin of fecal contamination in waters from contrasted areas: stanols as Microbial Source Tracking markers. | 2012 | Water Res. | pmid:22673347 |