Dihydrocholesterol is a lipid of Sterol Lipids (ST) class. Dihydrocholesterol is associated with abnormalities such as Exanthema, Morphologically altered structure, protrusion, Dehydration and Xanthoma. The involved functions are known as Regulation, Biochemical Pathway, Methylation, Metabolic Inhibition and Biosynthetic Pathways. Dihydrocholesterol often locates in envelope, Mitochondria, Lipid Bilayers, Host Cell and Membrane. The associated genes with Dihydrocholesterol are GRAP2 gene, PTP4A2 gene, HSD3B7 gene, MBD2 gene and IGF2BP3 gene. The related lipids are Sterols, Cardiolipins, Pregnanes, 7-hydroxy-4-cholesten-3-one and Hydroxycholesterols. The related experimental models are Mouse Model.
To understand associated biological information of Dihydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Dihydrocholesterol is suspected in Xanthoma, Xanthomatosis, Cerebrotendinous, Coronary heart disease, Exanthema, Morphologically altered structure, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Dihydrocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase.' (BÃ¥vner A et al., 2010).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Osman R et al. | Chemometric application in identifying sources of organic contaminants in Langat river basin. | 2012 | Environ Monit Assess | pmid:21494831 |
| Jusakul A et al. | Liver fluke-induced hepatic oxysterols stimulate DNA damage and apoptosis in cultured human cholangiocytes. | 2012 | Mutat. Res. | pmid:22044627 |
| Kurvinen A et al. | Parenteral plant sterols and intestinal failure-associated liver disease in neonates. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22197940 |
| Lahti M and Oikari A | Vertical distribution of pharmaceuticals in lake sediments-citalopram as potential chemomarker. | 2012 | Environ. Toxicol. Chem. | pmid:22639393 |
| Suh S et al. | Three siblings with Cerebrotendinous Xanthomatosis: a novel mutation in the CYP27A1 gene. | 2012 | Eur J Med Genet | pmid:21958693 |
| Koyama S et al. | A case of cerebrotendinous xanthomatosis presenting with epilepsy as an initial symptom with a novel V413D mutation in the CYP27A1 gene. | 2012 | Clin Neurol Neurosurg | pmid:22336472 |
| Ostrowska M et al. | Cerebrotendinous xanthomatosis: a rare cause of spinocerebellar syndrome. | 2011 Nov-Dec | Neurol. Neurochir. Pol. | pmid:22212991 |
| Pilo de la Fuente B et al. | [Usefulness of cholestanol levels in the diagnosis and follow-up of patients with cerebrotendinous xanthomatosis]. | 2011 | Neurologia | pmid:21345536 |
| Wolff E et al. | Cholesterol-absorber status modifies the LDL cholesterol-lowering effect of a Mediterranean-type diet in adults with moderate cardiovascular risk factors. | 2011 | J. Nutr. | pmid:21865559 |
| Daly TA et al. | The origin of cholesterol's condensing effect. | 2011 | Langmuir | pmid:21319766 |