27-hydroxy-cholesterol(25r) is a lipid of Sterol Lipids (ST) class. 27-hydroxy-cholesterol(25r) is associated with abnormalities such as Consumption-archaic term for TB and Kozlowski Celermajer Tink syndrome. The involved functions are known as CYP27A1activity, mRNA Expression, Anabolism, Steroid biosynthesis and Metabolic Process, Cellular. 27-hydroxy-cholesterol(25r) often locates in Body tissue, soluble, Mitochondria and Inner mitochondrial membrane. The associated genes with 27-hydroxy-cholesterol(25R) are ABRA gene, IGKV1-16 gene, HSD3B1 gene, CYP21A2 gene and TSPO gene. The related lipids are Steroids and cholesterol analog.
To understand associated biological information of 27-hydroxy-cholesterol(25R), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
27-hydroxy-cholesterol(25R) is suspected in Kozlowski Celermajer Tink syndrome and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 27-hydroxy-cholesterol(25R)
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Marwarha G et al. | The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease. | 2011 | J. Neurochem. | pmid:21951066 |
| Seet RC et al. | Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? | 2011 | Free Radic. Biol. Med. | pmid:21420490 |
| Blom T et al. | FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. | 2010 | Circ. Res. | pmid:20056921 |
| Dasari B et al. | The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. | 2010 | BMC Ophthalmol | pmid:20836858 |
| Iuliano L et al. | Vitamin E and enzymatic/oxidative stress-driven oxysterols in amnestic mild cognitive impairment subtypes and Alzheimer's disease. | 2010 | J. Alzheimers Dis. | pmid:21504117 |
| Crow JA et al. | Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. | 2010 | Biochim. Biophys. Acta | pmid:19761868 |
| DuSell CD et al. | The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. | 2010 | Endocrinology | pmid:20501668 |
| Marwarha G et al. | Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. | 2010 | J. Alzheimers Dis. | pmid:20157255 |
| Taylor JM et al. | Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI. | 2010 | Cardiovasc. Res. | pmid:20083572 |
| Schüle R et al. | Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. | 2010 | J. Lipid Res. | pmid:19812052 |