27-hydroxy-cholesterol(25r) is a lipid of Sterol Lipids (ST) class. 27-hydroxy-cholesterol(25r) is associated with abnormalities such as Consumption-archaic term for TB and Kozlowski Celermajer Tink syndrome. The involved functions are known as CYP27A1activity, mRNA Expression, Anabolism, Steroid biosynthesis and Metabolic Process, Cellular. 27-hydroxy-cholesterol(25r) often locates in Body tissue, soluble, Mitochondria and Inner mitochondrial membrane. The associated genes with 27-hydroxy-cholesterol(25R) are ABRA gene, IGKV1-16 gene, HSD3B1 gene, CYP21A2 gene and TSPO gene. The related lipids are Steroids and cholesterol analog.
To understand associated biological information of 27-hydroxy-cholesterol(25R), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
27-hydroxy-cholesterol(25R) is suspected in Kozlowski Celermajer Tink syndrome and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 27-hydroxy-cholesterol(25R)
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Marwarha G et al. | Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. | 2010 | J. Alzheimers Dis. | pmid:20157255 |
| Riendeau V and Garenc C | Effect of 27-hydroxycholesterol on survival and death of human macrophages and vascular smooth muscle cells. | 2009 | Free Radic. Res. | pmid:19672739 |
| Olkkonen VM and Hynynen R | Interactions of oxysterols with membranes and proteins. | 2009 | Mol. Aspects Med. | pmid:19248802 |
| Gilardi F et al. | Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling. | 2009 | Neuroscience | pmid:19665519 |
| Mateos L et al. | Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro. | 2009 | Brain Pathol. | pmid:18503570 |
| Koschack J et al. | Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals. | 2009 | Neurobiol. Aging | pmid:18061309 |
| van den Kommer TN et al. | Total cholesterol and oxysterols: early markers for cognitive decline in elderly? | 2009 | Neurobiol. Aging | pmid:17888546 |
| Solomon A et al. | Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. | 2009 | Neurosci. Lett. | pmid:19560513 |
| Kim WS et al. | Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons. | 2009 | J. Alzheimers Dis. | pmid:19158428 |
| Morello F et al. | LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. | 2009 | Atherosclerosis | pmid:19426978 |